ReviewOpen forum infectious diseases2026
Molecular Relatedness of Maternal and Neonatal Multidrug-Resistant Gram-Negative Colonization Isolates in Low- and Middle-Income Countries: A Systematic Review.
Review in Open forum infectious diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Multidrug-resistant gram-negative (MDR-GN) sepsis is a significant cause of neonatal mortality in low- and middle-income countries (LMICs). The role of vertical transmission in neonatal MDR-GN colonization and thereby invasive infection remains unknown. The aim of this study was to systematically review literature detailing the molecular relatedness of maternal and neonatal MDR-GN colonization isolates in LMICs, characterizing the extent of vertical transmission. Methods: Following PRISMA guidelines, PubMed and Scopus databases were searched for LMIC literature reporting molecular evidence of MDR-GN concordance for mother-neonate dyads. Results: Of 90 articles identified by the search, 11 met inclusion criteria. Findings demonstrated substantial MDR-GN colonization in dyads from LMICs, although with significant heterogeneity in sampling methods. From MDR-GN dyads, molecular methods rarely found relatedness. Many studies suggested horizontal transmission within the environment. Conclusions: In LMICs, maternal MDR-GN colonization rarely results in vertical transmission to neonates. However, literature remains scarce and further research is needed.
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