Evidence map›Paper›PMID 41648077›Full record

ArticleOpen forum infectious diseases2026

Distinct Clinico-pathogenic Subgroups in Pediatric Lyme Neuroborreliosis.

Semjon Sidorov, Beat M Greiter, Ester Osuna, Annette Hackenberg, Michelle Seiler, Roland Martin, Martina Marchesi, Stefanie von Felten, Adrian Egli, Christoph Berger and 1 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in Open forum infectious diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Semjon SidorovDivision of Infectious Diseases and Hospital Epidemiology, Children's Research Center, University Children's Hospital Zurich, University of Zurich, Zurich, Switzerland.ORCID https://orcid.org/0000-0001-5300-664X
Beat M GreiterDivision of Infectious Diseases and Hospital Epidemiology, Children's Research Center, University Children's Hospital Zurich, University of Zurich, Zurich, Switzerland.ORCID https://orcid.org/0009-0000-2445-7134
Ester OsunaDivision of Infectious Diseases and Hospital Epidemiology, Children's Research Center, University Children's Hospital Zurich, University of Zurich, Zurich, Switzerland.ORCID https://orcid.org/0000-0001-7706-6102
Annette HackenbergDepartment of Neurology, Children's Research Center, University Children's Hospital Zurich, University of Zurich, Zurich, Switzerland.ORCID https://orcid.org/0000-0003-3161-8703
Michelle SeilerEmergency Department, Children's Research Center, University Children's Hospital Zurich, University of Zurich, Zurich, Switzerland.ORCID https://orcid.org/0000-0002-1263-5818
Roland MartinInstitute of Experimental Immunology, University of Zurich, Zurich, Switzerland.ORCID https://orcid.org/0000-0002-0982-1329
Martina MarchesiInstitute of Medical Microbiology, University of Zurich, Zurich, Switzerland.ORCID https://orcid.org/0000-0003-3076-1735
Stefanie von FeltenDepartment of Biostatistics at Epidemiology, Biostatistics and Prevention Institute (EBPI), University of Zurich, Zurich, Switzerland.ORCID https://orcid.org/0000-0002-5264-6394
Adrian EgliInstitute of Medical Microbiology, University of Zurich, Zurich, Switzerland.ORCID https://orcid.org/0000-0002-3564-8603
Christoph BergerDivision of Infectious Diseases and Hospital Epidemiology, Children's Research Center, University Children's Hospital Zurich, University of Zurich, Zurich, Switzerland.ORCID https://orcid.org/0000-0002-2373-8804
Patrick M Meyer SauteurDivision of Infectious Diseases and Hospital Epidemiology, Children's Research Center, University Children's Hospital Zurich, University of Zurich, Zurich, Switzerland.ORCID https://orcid.org/0000-0002-4312-9803

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Lyme neuroborreliosis (LNB) is a common manifestation of Lyme disease in children. It is caused by the bacterium Methods: We performed a large retrospective cohort study of children diagnosed with LNB at the University Children's Hospital Zurich from 1 January 2006 to 31 December 2020. Results: A total of 190 children diagnosed with LNB were included (median age, 7.6 years). Meningitis was the most frequent manifestation of LNB ( Conclusions: Lyme neuroborreliosis in children presents with a broad clinical spectrum, with meningitis and iCN being the most common manifestations. We observed distinct clinico-pathogenic subgroups of LNB: iCN reflects a more localized, PNS-restricted disease, whereas meningitis and meningoradiculitis represent a more systemic involvement of both PNS and CNS. These findings may improve diagnostic accuracy and guide the management of children with LNB.

Indexed as

Borrelia burgdorferifacial nerve palsyintrathecal antibody productionLyme diseasemeningitis

Identifiers

PMID41648077
PMCPMC12871429

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.