ArticleResuscitation plus2026
Association between early arterial pH, base excess and lactate and 24-h mortality and neurological outcomes after cardiac arrest and cardiopulmonary resuscitation: a translational study.
Article in Resuscitation plus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Good neurological outcome after traumatic cardiopulmonary arrest with extreme acidosis (pH 6.62): a case report.Resuscitation plus · 2026Article
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Authors and funding
9 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Aim: We aimed to assess the translational relevance of blood gas-derived acid-base parameters measured in rat and pig models of cardiac arrest and cardiopulmonary resuscitation, evaluating their potential as predictors of mortality and poor neurological outcome. Methods: Seventy-seven rats, 83 pigs and 61 patients who experienced cardiac arrest of proven or suspected cardiac origin were retrospectively analyzed Results: In a multivariate regression analysis area under the curve, considering pH, base excess and lactate, for prediction of mortality were respectively: 0.796 (95%CI: 0.635-0.956), 0.980 (95%CI: 0.946-1.000), 0.959 (95%CI: 0.896-1.000) in rats; 0.908 (95%CI: 0.826-0.990), 0.933 (95%CI: 0.863-1.000), 0.798 (95%CI: 0.588-1.000) in pigs; and 0.830 (95%CI: 0.724-0.936), 0.832 (95%CI: 0.731-0.933), 0.839 (95%CI: 0.738-0.940) in patients. Area under the curve, considering pH, base excess and lactate, for prediction of poor neurological outcome were respectively: 0.673 (95%CI: 0.515-0.831), 0.724 (95%CI: 0.576-0.872), 0.900 (95%CI: 0.760-1.000) in pigs; and 0.835 (95%CI: 0.734-0.937), 0.835 (95%CI: 0.735-0.936), 0.884 (95%CI: 0.793-0.945) in patients. Conclusion: Arterial pH, base excess and lactate were early independent predictors of both 24-h mortality and neurological outcome following cardiac arrest in animal models and in humans. BE showed the highest predictive value for mortality, while lactate was the strongest predictor for poor neurological outcome.
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