Evidence map›Paper›PMID 41648058›Full record

ArticleMedComm2026

Cleavage and Polyadenylation Specificity Factor Subunit 5 Regulates Pulmonary Artery Smooth Muscle Expansion and Hypoxic Response.

Scott D Collum, Lisha Zhu, Tingting W Mills, Rene Girard, Jamie Tran, Tinne C J Mertens, Cory Wilson, Nancy Wareing, Erik E Suarez, Howard J Huang and 8 more

Abstract read
In one paragraph

Article in MedComm, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Scott D CollumDepartment of Biochemistry and Molecular Biology, McGovern Medical School University of Texas Health Science Center Houston Houston Texas USA.
Lisha ZhuData Science and Informatics Core For Cancer Research, McWilliams School of Biomedical Informatics University of Texas Health Science Center Houston Houston Texas USA.
Tingting W MillsDepartment of Biochemistry and Molecular Biology, McGovern Medical School University of Texas Health Science Center Houston Houston Texas USA.
Rene GirardDepartment of Biochemistry and Molecular Biology, McGovern Medical School University of Texas Health Science Center Houston Houston Texas USA.
Jamie TranDepartment of Biochemistry and Molecular Biology, McGovern Medical School University of Texas Health Science Center Houston Houston Texas USA.
Tinne C J MertensDepartment of Biochemistry and Molecular Biology, McGovern Medical School University of Texas Health Science Center Houston Houston Texas USA.
Cory WilsonDepartment of Biochemistry and Molecular Biology, McGovern Medical School University of Texas Health Science Center Houston Houston Texas USA.
Nancy WareingDepartment of Internal Medicine Emory University School of Medicine Atlanta Georgia USA.
Erik E SuarezDeBakey Heart and Vascular Center Houston Methodist Hospital Houston Texas USA.
Howard J HuangDeBakey Heart and Vascular Center Houston Methodist Hospital Houston Texas USA.
Rahat HussainDepartment of Internal Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, McGovern Medical School University of Texas Health Science Center Houston Houston Texas USA.
Bindu AkkantiDepartment of Internal Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, McGovern Medical School University of Texas Health Science Center Houston Houston Texas USA.
Wenjin J ZhengData Science and Informatics Core For Cancer Research, McWilliams School of Biomedical Informatics University of Texas Health Science Center Houston Houston Texas USA.
Hari K YalamanchiliDepartment of Department of Pediatrics Baylor College of Medicine Houston Texas USA.
Bela PatelDepartment of Internal Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, McGovern Medical School University of Texas Health Science Center Houston Houston Texas USA.
Eric J WagnerDepartment of Biochemistry and Biophysics The University of Rochester Medical Center Rochester New York USA.
Sandeep AgarwalDepartment of Medicine, Section of Immunology, Allergy and Rheumatology Baylor College of Medicine Houston Texas USA.
Harry Karmouty-QuintanaDepartment of Biochemistry and Molecular Biology, McGovern Medical School University of Texas Health Science Center Houston Houston Texas USA.

Funding

Sineoculis Homeobox Homolog 1 (Six1) in Pulmonary FibrosisR01HL157100 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI KARMOUTY-QUINTANA, HARRY · 2021 to 2025
$2.8M
3'UTR Shortening In Pulmonary Vascular DiseaseR01HL138510 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI KARMOUTY-QUINTANA, HARRY · 2017 to 2021
$2.3M
CFlm25 mediated alternative polyadenylation regulates fibrosis in systemic sclerosisR01AR073284 · NIAMS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI ASSASSI, SHERVIN, MILLS, TINGTING WENG · 2019 to 2023
$1.7M
Macrophage NUDT21-mediated alternative polyadenylation in lung injuryR01HL168128 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI Tingting Weng Mills · 2024 to 2026
$1.6M
NHLBI NIH HHS R01 HL138510NHLBI NIH HHS R01 HL157100NHLBI NIH HHS R01 HL168128NIAMS NIH HHS R01 AR073284
6 · The paper itself

Abstract

Pulmonary hypertension (PH) is a fatal condition that affects individuals with systemic sclerosis (SSc), a multiorgan fibrotic disease with limited treatment options. A central feature of PH is vascular remodeling, defined by the narrowing of the arteriole lumen due to cell proliferation and extracellular matrix deposition. Herein, we identify a central mechanism that can regulate multiple transcripts important for vascular remodeling. The highlight of our study is the demonstration that reduced pulmonary artery smooth muscle (PASMC)

Indexed as

cell proliferationCPSF5EP3prostaglandin E receptor 3 (PTGER3)pulmonary arterial hypertensionRUNX1SSc‐ILDsystemic sclerosisvascular tone

Identifiers

PMID41648058
PMCPMC12868934

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.