ArticleESMO gastrointestinal oncology2025
Fertility and sexuality in early-onset colorectal cancer patients: a monocentric survey.
Article in ESMO gastrointestinal oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Early-Onset Colorectal Cancer: From Epidemiologic Shift to Life-Course Carcinogenesis and Age-Attuned Care.Current oncology reports · 2026Review
- Female Oncofertility in Colorectal Cancer: Reproductive Uncertainties and Potential Benefits of Immunotherapy.Journal of clinical medicine · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Evidence concerning the impact of chemotherapy on sexual health and fertility in early-onset colorectal cancer (EO-CRC) patients is scarce. Patients and methods: We aimed to assess through an anonymous online survey the effect of chemotherapy on sexual quality of life and fertility preservation management in patients with stage II-IV EO-CRC treated at our center. Sexual health was evaluated with the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Sexual Health (EORTC QLQ-SH22) questionnaire. Fertility issues were assessed through a structured survey form. Results: From 2010 to 2022, 139 out of 6444 patients were diagnosed with EO-CRC at our center. A total of 84 patients (60.4%) completed the survey, while 55 (39.6%) did not participate; 50 (59.5%) were women and 42 (50%) had stage II-III disease. Only 11.9% (8/67) of patients reported having discussed sexual issues with their oncologist, while 45% (18/40) received specific counseling about fertility preservation, with no statistically significant differences between sexes. Libido decrease and sexual pain were reported more often by women compared with men in each setting; the difference was statistically significant ( Conclusions: Clinicians tend to discuss fertility issues more often than sexual health with patients, regardless of sex. Women seem to experience more libido decrease and sexual pain compared with men, and their risk of persistent amenorrhea increases with age. Both fertility and sexuality counseling should be improved in EO-CRC management.
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