Evidence map›Paper›PMID 41647987›Full record

ArticleESMO gastrointestinal oncology2025

Lymph node mapping-based optimal bowel-resection margin and central radicality in colon cancer surgery: an international, prospective, observational cohort study.

H Ueno, N K Kim, J C Kim, P Tsarkov, W Hohenberger, R Grützmann, N E Samalavičius, A Dulskas, J-T Liang, P Quirke and 28 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ESMO gastrointestinal oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

38 authors.

H UenoDepartment of Surgery, National Defense Medical College, Saitama, Japan.
N K KimDepartment of Surgery, Yonsei University College of Medicine, Seoul, Republic of Korea.
J C KimDivision of Colon and Rectal Surgery, Department of Surgery, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea.
P TsarkovDepartment of Surgery, Faculty of Preventive Medicine, Clinic of Colorectal and Minimally Invasive Surgery, Sechenov First Moscow State Medical University, Moscow, Russia.
W HohenbergerDepartment of Surgery, University Hospital Erlangen, Friedrich-Alexander-University of Erlangen-Nuremberg, Erlangen, Germany.
R GrützmannDepartment of Surgery, University Hospital Erlangen, Friedrich-Alexander-University of Erlangen-Nuremberg, Erlangen, Germany.
N E SamalavičiusCenter of General Surgery, Republican Vilnius University Hospital, Vilnius, Lithuania.
A DulskasDepartment of General and Abdominal Surgery and Oncology, National Cancer Institute, Vilnius, Lithuania.
J-T LiangDivision of Colorectal Surgery, Department of Surgery, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan.
P QuirkePathology and Data Analytics, Leeds Institute of Medical Research at St. James's, University of Leeds, Leeds, UK.
N WestPathology and Data Analytics, Leeds Institute of Medical Research at St. James's, University of Leeds, Leeds, UK.
A ShiomiDivision of Colorectal Surgery, Shizuoka Cancer Center Hospital, Shizuoka, Japan.
M ItoColorectal and Pelvic Surgery Division, Department of Surgical Oncology, National Cancer Center Hospital East, Chiba, Japan.
M ShiozawaDepartment of Gastrointestinal Surgery, Kanagawa Cancer Center, Kanagawa, Japan.
K KomoriDepartment of Gastroenterological Surgery, Aichi Cancer Center Hospital, Aichi, Japan.
K MatsudaSecond Department of Surgery, School of Medicine, Wakayama Medical University, Wakayama, Japan.
Y KinugasaDepartment of Gastrointestinal Surgery, Institute of Science Tokyo, Tokyo, Japan.
T SatoDepartment of Surgery, Yamagata Prefectural Central Hospital, Yamagata, Japan.
K YamadaDepartment of Gastroenterological Surgery, Coloproctology Center, Takano Hospital, Kumamoto, Japan.
Y HashiguchiDepartment of Surgery, Teikyo University School of Medicine, Tokyo, Japan.
H OzawaDepartment of Surgery, Tochigi Cancer Center, Tochigi, Japan.
Y KanemitsuDepartment of Colorectal Surgery, National Cancer Center Hospital, Tokyo, Japan.
T KusumiDepartment of Surgery, Keiyukai Sappro Hospital, Hokkaido, Japan.
H IkeDepartment of Surgery, Saisei-kai Yokohama-shi Nanbu Hospital, Kanagawa, Japan.
Y TakiiDepartment of Surgery, Niigata Cancer Center Hospital, Niigata, Japan.
H MatsuokaDepartment of Surgery, Kyorin University School of Medicine, Tokyo, Japan.
Y ToiyamaDepartment of Gastrointestinal and Pediatric Surgery, Mie University Graduate School of Medicine, Mie, Japan.
J WatanabeDepartment of Surgery, Gastroenterological Center, Yokohama City University Medical Center, Kanagawa, Japan.
A IshibeDepartment of Gastroenterological Surgery, Yokohama City University Graduate School of Medicine, Kanagawa, Japan.
H SonodaDepartment of Surgery, Shiga University of Medical Science, Shiga, Japan.
K KodaDepartment of Surgery, Teikyo University Chiba Medical Center, Chiba, Japan.
F FujitaDepartment of Surgery, Kurume University School of Medicine, Fukuoka, Japan.
M OhueDepartment of Gastroenterological Surgery, Osaka International Cancer Institute, Osaka, Japan.
M ItabashiDepartment of Surgery, Institute of Gastroenterology, Tokyo Women's Medical University, Tokyo, Japan.
M TaketsunaTranslational Research Center for Medical Innovation, Foundation for Biomedical Research and Innovation, Hyogo, Japan.
S HigashideTranslational Research Center for Medical Innovation, Foundation for Biomedical Research and Innovation, Hyogo, Japan.
Y AjiokaDivision of Molecular and Diagnostic Pathology, Graduate School of Medical and Dental Science, Niigata University, Niigata, Japan.
K SugiharaInstitute of Science Tokyo, Tokyo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Substantial variations in the extent of lymphadenectomy are acknowledged internationally in colon cancer surgery because essential data for standardization, including the anatomical distribution of metastatic lymph nodes (LN), are lacking. Materials and methods: Pre-specified LN mappings based on Results: Among 3647 patients, pericolic spread beyond 10 cm (0.2%) and absence of feeding arteries supplying the bowel within 10 cm from the primary tumor (0.3%) were rare, irrespective of nationality. The incidence of metastasis in central LNs was ∼3% (range: 0.2% in T1 to 7% in T4 tumors) and was lower in tumors located at the splenic flexure (0.5%). The proportion of patients with level C radicality was ∼76%, which was statistically significantly associated with T stage only in one country. A higher radicality level conferred no adverse impact on either the incidence of Clavien-Dindo grade ≥III or 30-day mortality. Conclusions: The '10-cm rule' could be an international criterion for determining the bowel-resection margin. Central lymphadenectomy is feasible internationally, though the indication should be selective, not routine, depending on the stage and location of the primary tumor.

Indexed as

bowel-resection margincentral radicalitycolon cancercomplete mesocolic excisionD3 lymph node dissectionlymph node mapping

Identifiers

PMID41647987
PMCPMC12836715

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.