Evidence map›Paper›PMID 41647985›Full record

ArticleESMO gastrointestinal oncology2025

Continuum of care and survival in patients with metastatic colorectal cancer: results of the real-world prospective, longitudinal cohort PROMETCO study.

M Koopman, R Garcia-Carbonero, C Pinto, A Mitroshkin, G Bodoky, L Mineur, V Bourgeois, M Mare, A Ruiz-Casado, A Fernandez Montes and 6 more

Abstract read
In one paragraph

Article in ESMO gastrointestinal oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

M KoopmanDepartment of Medical Oncology, University Medical Centre Utrecht, Utrecht University, Utrecht, The Netherlands.
R Garcia-CarboneroOncology Department, Hospital Universitario Doce de Octubre, Imas12, Facultad y Departamento de Medicina, Universidad Complutense de Madrid (UCM), Madrid, Spain.
C PintoMedical Oncology, Comprehensive Cancer Centre, AUSL - IRCCS di Reggio Emilia - Reggio Emilia, Italy.
A MitroshkinKlinikum Freudenstadt, Akademisches Lehrkrankenhaus der Universität Tübingen, Freudenstadt, Germany.
G BodokyDél-Pesti Centrumkórház, Szent László Telephely, Budapest, Hungary.
L MineurGI and Liver Oncology Unit, Institut of Cancer Sainte Catherine Avignon Provence, Avignon, France.
V BourgeoisBoulogne-sur-Mer Hospital Center, Rue Jacques Monod, Boulogne-sur-Mer, France.
M MareMedical Oncology Unit, Mediterranean Institute of Oncology, Catania, Italy.
A Ruiz-CasadoDepartment of Medical Oncology, Hospital Universitario Puerta de Hierro, Majadahonda, IDIPHISA, Madrid, Spain.
A Fernandez MontesComplexo Hospitalario Universitario de Ourense, Calle Ramon Puga Noguerol, Orense, Spain.
J M O'ConnorInstituto Alexander Fleming, Buenos Aires, Argentina.
A SullivanServier Pharmaceuticals, Boston, USA.
E ChoucairServier, Suresnes, France.
B ChevallierServier, Suresnes, France.
F Marti MartiDepartment of Medical Oncology, The Christie NHS Foundation Trust, Manchester, UK.
J-B BachetSorbonne Université, Service d'hépato-Gastro-Entérologie, Groupe Hospitalier Pitié Salpêtrière, APHP, Paris, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: PROMETCO is the first international, prospective study investigating the continuum of care, including prescribing patterns, efficacy and safety in patients with metastatic colorectal cancer (mCRC) at later therapy lines in a real-world setting. Materials and methods: Adults with mCRC and two disease progressions since diagnosis of mCRC who were willing to receive subsequent treatment and gave informed consent were included. The study consisted of retrospective medical chart data collection pre-inclusion and a prospective observational period post-inclusion. Endpoint data presented include patient characteristics, treatment patterns and efficacy including progression-free survival (PFS) per treatment line and overall survival (OS). Results: As of July 2023, 738 mCRC patients from 96 centres in 18 countries were recruited. 48.9% of patients had Conclusions: PROMETCO provided information on real-world prescribing patterns and efficacy. OS from mCRC diagnosis and PFS from 3L and beyond were similar to previous long-term follow-up data from clinical trials.

Indexed as

mCRCoverall survivalreal-world datathird-line

Identifiers

PMID41647985
PMCPMC12836624

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.