Evidence map›Paper›PMID 41647984›Full record

ArticleESMO gastrointestinal oncology2025

Dietary and lifestyle inflammation scores in relation to colon cancer recurrence in subgroups of patients based on common molecular tumour characteristics.

E Wesselink, D E Kok, K C Smit, A-S van Lanen, J W G Derksen, M Koopman, M Ligtenberg, I D Nagtegaal, P D M Rombout, J H W de Wilt and 3 more

Abstract read
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In one paragraph

Article in ESMO gastrointestinal oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

E WesselinkDivision of Human Nutrition and Health, Wageningen University & Research, Wageningen, The Netherlands.
D E KokDivision of Human Nutrition and Health, Wageningen University & Research, Wageningen, The Netherlands.
K C SmitJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
A-S van LanenDivision of Human Nutrition and Health, Wageningen University & Research, Wageningen, The Netherlands.
J W G DerksenJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
M KoopmanDepartment of Medical Oncology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
M LigtenbergDepartment of Human Genetics, Radboud University Medical Center, University of Nijmegen, Nijmegen, The Netherlands.
I D NagtegaalDepartment of Pathology, Radboud University Medical Center, University of Nijmegen, Nijmegen, The Netherlands.
P D M RomboutDepartment of Pathology, Radboud University Medical Center, University of Nijmegen, Nijmegen, The Netherlands.
J H W de WiltDepartment of Surgery, Radboud University Medical Center, University of Nijmegen, Nijmegen, The Netherlands.
E KampmanDivision of Human Nutrition and Health, Wageningen University & Research, Wageningen, The Netherlands.
A M MayJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
F J B van DuijnhovenDivision of Human Nutrition and Health, Wageningen University & Research, Wageningen, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The aim of this study was to investigate associations between the inflammatory potential of diet and lifestyle in relation to colon cancer recurrence in subgroups of patients based on molecular tumour characteristics that also influence the inflammatory tumour microenvironment. Patients and methods: A nested case-control study was implemented in two prospective cohort studies of colon cancer patients. Participants who developed a recurrence were included as cases ( Results: A more pro-inflammatory diet was not associated with risk of recurrence [incidence rate ratio (IRR) 1.04, 95% confidence interval (CI) 0.96-1.12]. Persons who have a more pro-inflammatory lifestyle may have an increased recurrence risk (IRR 1.21, 95% CI 0.97-1.52), which was most pronounced for persons with MSS and Conclusion: Our results suggest that associations between the LIS and recurrence might differ based on molecular tumour characteristics.

Indexed as

colon cancer recurrencedietary inflammation scoreslifestyle inflammation scoresmolecular tumour characteristics

Identifiers

PMID41647984
PMCPMC12836590

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.