ArticleAfrican journal of laboratory medicine2026
Age- and gender-based frequency and association of common myeloproliferative mutations in a South African cohort.
Article in African journal of laboratory medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Age, gender, and mutation type are key risk factors for myeloproliferative neoplasms (MPNs). Africa remains under-represented in global cancer statistics due to limited population-based genomic data. Objective: To determine the frequency and demographic associations of common MPN-related genetic abnormalities in the South African population. Methods: A retrospective cross-sectional analysis of cytogenetic results for Results: A total of 8934 patient records were analysed; 58% were male patients and 42% female patients, with a mean age of 50 ± 17 years. Among sequence variant changes, 18.2% of MPN cases were positive for Conclusion: What this study adds: MPN genetic testing in South Africa predominantly targeted male patients (ratio 1.4:1).
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