Evidence map›Paper›PMID 41647920›Full record

ArticleiGIE : innovation, investigation and insights2024

Clinical safety of a novel over-the-scope gastroduodenal full-thickness resection device for the treatment of upper GI tract lesions: a multicenter experience.

Alyssa Y Choi, Peter H Nguyen, Jaehyun Kim, Julie Yang, Sherif A Andrawes, Jean Chalhoub, Anastasia Chahine, Andrew Q Giap, David P Lee, Kenneth H Park and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iGIE : innovation, investigation and insights, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Alyssa Y ChoiDivision of Gastroenterology and Hepatology, University of California Irvine School of Medicine, Orange, California, USA.
Peter H NguyenDivision of Internal Medicine, University of California Irvine School of Medicine, Orange, California, USA.
Jaehyun KimDivision of Gastroenterology and Hepatology, University of California Irvine School of Medicine, Orange, California, USA.
Julie YangHenry D. Janowitz Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Sherif A AndrawesDivision of Gastroenterology, Staten Island University Hospital, Staten Island, New York, USA.
Jean ChalhoubDivision of Gastroenterology, Staten Island University Hospital, Staten Island, New York, USA.
Anastasia ChahineDivision of Internal Medicine, University of California Irvine School of Medicine, Orange, California, USA.
Andrew Q GiapDivision of Gastroenterology, Kaiser Permanente, Anaheim, California, USA.
David P LeeDivision of Gastroenterology, Methodist Dallas Medical Center, Dallas, Texas, USA.
Kenneth H ParkDivision of Gastroenterology and Hepatology, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Quin Y LiuDivision of Gastroenterology and Hepatology, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Srinivas GaddamDivision of Gastroenterology and Hepatology, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Kendrick CheDivision of Gastroenterology, Loma Linda University Health, Loma Linda, California, USA.
Michael LajinDivision of Gastroenterology, Sharp Grossmont Hospital, La Mesa, California, USA.
Wasseem SkefDivision of Gastroenterology and Hepatology at Baylor College of Medicine, Michael E. DeBakey VA Medical Center, Houston, Texas, USA (10).
Amirali TavangarDivision of Gastroenterology and Hepatology, University of California Irvine School of Medicine, Orange, California, USA.
John J KimDivision of Gastroenterology, Loma Linda University Health, Loma Linda, California, USA.
Jason B SamarasenaDivision of Gastroenterology and Hepatology, University of California Irvine School of Medicine, Orange, California, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and Aims: A novel gastroduodenal full-thickness resection device system was developed for resection of upper GI tract lesions. In this study, we evaluated the efficacy and safety of the gastroduodenal full-thickness resection device system. Methods: Consecutive patients who received endoscopic resection of upper GI tract lesions from June 2020 to August 2022 using a gastroduodenal full-thickness resection device were evaluated from 8 U.S. centers. Primary endpoints were technical success and R0 resection. Secondary endpoints were en bloc resection, residual lesions at follow-up endoscopy, and immediate or delayed adverse events. Results: Forty-four patients (mean age, 60.9 ± 15.8 years) received 45 resections for gastric (35, 80%) and duodenal (9, 20%) lesions. Thirty-four lesions (77%) were subepithelial and 10 (23%) were epithelial lesions. Technical success and en bloc resection were achieved in 43 (96%) and 41 (91%) patients, respectively. Furthermore, R0 resection was achieved in 32 patients (71%), including 24 of 35 (69%) with neoplastic lesions. Pathologic diagnosis included neuroendocrine tumor in 14 patients (32%), GI stromal tumor in 10 (23%), and gastric cancer or high-grade dysplasia in 7 (16%). Minor immediate and delayed bleeding occurred in 17 (38%) and 2 (4%) patients, respectively. One patient had delayed perforation, managed conservatively. On follow-up, 19 of 21 patients (90%) had no residual lesion. Conclusions: In this multicenter series, the gastroduodenal full-thickness resection device demonstrated high rates of technical success and acceptable rate of R0 resection. Immediate minor bleeding was common, whereas serious adverse events were rare. This gastroduodenal full-thickness resection device should be considered in patients with gastroduodenal subepithelial lesions as an alternative to long-term surveillance.

Identifiers

PMID41647920
PMCPMC12850798

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.