Evidence map›Paper›PMID 41647728›Full record

ArticleESMO gastrointestinal oncology2023

Clinical and genomic characterization of pancreatic ductal adenocarcinoma patients with lung oligometastasis.

N S Tissera, M Chiaravalli, A Turpin, R Luca, F Castet, C Fabregat-Franco, G Castillo, D López-Valbuena, G Tortora, P Hammel and 5 more

Abstract read
In one paragraph

Article in ESMO gastrointestinal oncology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

N S TisseraUpper Gastrointestinal Cancer Translational Research Group, Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain.
M ChiaravalliUnit of Medical Oncology, Comprehensive Cancer Center, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.
A TurpinUpper Gastrointestinal Cancer Translational Research Group, Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain.
R LucaDepartment of Gastrointestinal Oncology, Instituto Alexander Fleming, Buenos Aires, Argentina.
F CastetUpper Gastrointestinal Cancer Translational Research Group, Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain.
C Fabregat-FrancoUpper Gastrointestinal Cancer Translational Research Group, Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain.
G CastilloOncology Data Science Group, Vall d'Hebron Institute of Oncology (VHIO), Hospital Universitari Vall d'Hebron, Barcelona, Spain.
D López-ValbuenaUpper Gastrointestinal Cancer Translational Research Group, Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain.
G TortoraUnit of Medical Oncology, Comprehensive Cancer Center, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.
P HammelDepartment of Digestive and Medical Oncology, University Paris-Saclay, Paul Brousse Hospital (AP-HP), Villejuif, France.
J M O'ConnorDepartment of Gastrointestinal Oncology, Instituto Alexander Fleming, Buenos Aires, Argentina.
J MatitoCancer Genomics Group, Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain.
A VivancosCancer Genomics Group, Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain.
T V TianUpper Gastrointestinal Cancer Translational Research Group, Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain.
T MacarullaUpper Gastrointestinal Cancer Translational Research Group, Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Lung-only relapse following resection of pancreatic ductal adenocarcinoma (PDAC) is rare. While oligometastatic lung disease (OMLD) is detected after PDAC resection, its clinical and molecular features remain unclear. Our goal was to assess if lung metastatic lesion quantity and mutations could predict a better prognosis. Materials and methods: We carried out a multicentric retrospective analysis of clinical and genomic characteristics in PDAC patients with OMLD and compared them with those with non-oligometastatic lung-only disease (non-OMLD). Results: Thirty-nine patients meeting inclusion criteria were analyzed (OMLD Conclusions: Our study shows an OMLD incidence of 3.4% in PDAC patients after surgical resection. Patients with OMLD have distinct clinical characteristics compared to those with non-OMLD. PDAC driver mutations were found at similar rates in both groups. Further studies are needed for better understanding of OMLD and treatment strategies.

Indexed as

clinical characteristicslung metastasismolecular profilingoligometastasispancreatic ductal adenocarcinoma

Identifiers

PMID41647728
PMCPMC12836589

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.