ArticleESMO real world data and digital oncology2025
Guy's Cancer Cohort: Guy's Cancer Centre's Real-World Evidence Programme 5 years later.
Article in ESMO real world data and digital oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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22 authors.
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Abstract
Background: As the burden of cancer rises, the value of real-world data in addressing clinically relevant research questions is increasingly recognised. The Guy's Cancer Real-World Evidence Programme, initiated in 2018 at Guy's and St Thomas' Trust (GSTT), informs decision making and local policy. Within this programme, the Guy's Cancer Cohort (GCC) database has amplified real-world evidence (RWE) capabilities and improved data internalisation. GCC was renewed by the Research Ethics Committee in May 2023 (Ref: 23/NW/0105) and expanded to include patients investigated for new or recurrent cancer. Construction and content: GCC includes patients investigated, diagnosed, and/or treated for cancer, enabling case-control studies and the exploration of factors linked to cancer diagnosis. Annually, ∼8000 cancers are diagnosed at Guy's Cancer Centre. Only pseudonymised data are processed, and the database aligns with the National Health Service national opt-out scheme. Clinical data captured include demographics, tumour characteristics, treatments, quality of life, and imaging data. Conclusions: GCC provides essential infrastructure to explore clinical, mechanistic, and supportive care research questions. Its renewal and expansion optimise data collection and linkage, improving patient care and outcomes. Applications for pseudonymised datasets can be directed to cancerdata@gstt.nhs.uk.
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