Evidence map›Paper›PMID 41647703›Full record

ReviewESMO real world data and digital oncology2025

Real-world radiology data for artificial intelligence-driven cancer support systems and biomarker development.

D Navarro-Garcia, A Marcos, R Beets-Tan, L Blomqvist, Z Bodalal, D Deandreis, M Crispin-Ortuzar, F Gallagher, T Giandini, M J Graves and 8 more

Abstract readReview
In one paragraph

Review in ESMO real world data and digital oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

D Navarro-GarciaVall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain.
A MarcosVall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain.
R Beets-TanNetherlands Cancer Institute (NKI), Amsterdam, The Netherlands.
L BlomqvistDepartment of Nuclear Medicine/Hospital Physics, Karolinska University Hospital, Stockholm, Sweden.
Z BodalalNetherlands Cancer Institute (NKI), Amsterdam, The Netherlands.
D DeandreisGustave Roussy Cancer Center, UMR 1281 INSERM, CEA CNRS, Université Paris-Saclay, Paris, France.
M Crispin-OrtuzarUniversity of Cambridge, Cambridge, UK.
F GallagherUniversity of Cambridge, Cambridge, UK.
T GiandiniFondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
M J GravesUniversity of Cambridge, Cambridge, UK.
N LassauGustave Roussy Cancer Center, UMR 1281 INSERM, CEA CNRS, Université Paris-Saclay, Paris, France.
K Maier-HeinThe German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ), Heidelberg, Germany.
A PrelajFondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
P SchaderThe German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ), Heidelberg, Germany.
H-P SchlemmerThe German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ), Heidelberg, Germany.
O SedlaczekThe German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ), Heidelberg, Germany.
M VaianiFondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
R Perez-LopezVall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The integration of artificial intelligence (AI) and real-world data (RWD) opens up a new paradigm for exploiting radiology data to develop advanced diagnostic and therapeutic support systems. This review explores the advantages and challenges of utilizing vast digital image datasets from routine clinical practice and computational AI capabilities to enhance cancer patient care. Particularly, the application of AI to radiology data has shown promise in developing tools that automate clinical processes, such as tumor detection, while also identifying novel biomarkers in cancer for potential treatment support. Deep learning models, crucial for this transformation, require substantial data, making RWD a valuable resource for accelerating assay development. RWD offer diverse, extensive data reflecting real-world clinical practices, complementing clinical trial data and providing a broader understanding of patient populations and treatment responses. However, challenges such as data access, variability in quality, and processing complexities must be addressed. Standardizing data processing protocols and feature extraction methods is essential to ensure reproducibility and clinical applicability. Moreover, building trust among clinicians, patients, and regulatory bodies is crucial for successful implementation. This review highlights the potential of AI to analyze RWD imaging data and radiology reports, extracting relevant information and enhancing biomarker discovery. To facilitate practical use, we offer tools to address the main challenges associated with utilizing real-world imaging data, such as key aspects of image access and data processing.

Indexed as

artificial intelligencebiomarkersoncologyradiologyreal-world data

Identifiers

PMID41647703
PMCPMC12836605

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.