Evidence map›Paper›PMID 41647687›Full record

ArticleFrontiers in stroke2025

Value of routine heart rate variability parameters for atrial fibrillation detection in ischaemic stroke and high-risk TIA patients.

Kurt Moelgg, Anel Karisik, Lucie Buergi, Lukas Scherer, Luisa Delazer, Benjamin Dejakum, Silvia Felicetti, Theresa Koehler, Julian Granna, Christian Boehme and 9 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in stroke, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04582825 (STROKE-CARD REGISTRY), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04582825 active not recruitingnot on this map

STROKE-CARD REGISTRY: Extension of Standard Care in Patients With Ischemic Stroke and Transient Ischemic Attack

Typeobservational_patient_registrySponsorVASCage GmbHRan2020 to 2027Enrolled5,000ConditionsIschemic Stroke, Transient Ischemic AttackArmsN/A - Observational Study
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Kurt MoelggDepartment of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
Anel KarisikDepartment of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
Lucie BuergiDepartment of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
Lukas SchererDepartment of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
Luisa DelazerDepartment of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
Benjamin DejakumDepartment of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
Silvia FelicettiDepartment of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
Theresa KoehlerDepartment of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
Julian GrannaVASCage, Centre on Clinical Stroke Research, Innsbruck, Austria.
Christian BoehmeDepartment of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
Raimund PechlanerDepartment of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
Theresa ProckDepartment of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
Thomas ToellDepartment of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
Axel BauerDepartment of Internal Medicine III, Cardiology and Angiology, Medical University of Innsbruck, Innsbruck, Austria.
Michael SchreinlechnerDepartment of Internal Medicine III, Cardiology and Angiology, Medical University of Innsbruck, Innsbruck, Austria.
Daniel PavlukDepartment of Internal Medicine III, Cardiology and Angiology, Medical University of Innsbruck, Innsbruck, Austria.
Michael KnoflachDepartment of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
Stefan KiechlDepartment of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
Lukas Mayer-SuessDepartment of Neurology, Medical University of Innsbruck, Innsbruck, Austria.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Undetected atrial fibrillation (AF) increases the risk of recurrent ischaemic stroke, but current prediction scores do not incorporate heart rate variability (HRV) measures readily available from 24-h Holter ECGs. Methods: In 697 patients with non-AF ischaemic stroke or non-AF high-risk transient ischaemic attack (TIA) from the STROKE-CARD Registry (NCT04582825), we assessed eight time-domain HRV parameters for predicting incident AF within 1 year. ROC analyses, logistic regression, and the Youden index were used to identify optimal cut-offs and compare HRV performance with Brown-ESUS AF and AS5F scores. Results: New-onset AF was detected in 28 patients (4.0%). PNN50, rMSSD, and SDSD showed the best discrimination (AUC = 0.711, 0.766, and 0.775), outperforming both clinical scores (AUC ≤ 0.612). Optimal cut-offs were 5.5% (PNN50), 48.5 ms (rMSSD), and 43.5 ms (SDSD). Dichotomized analyses confirmed strong associations with AF (ORs 5.34-7.70, all Conclusions: PNN50, rMSSD, and SDSD from routine Holter ECGs enhance AF risk prediction after non-cardioembolic stroke or high-risk TIA and may support targeted monitoring strategies.

Indexed as

atrial fibrillationheart rate variabilityholter ECGischaemic strokerisk predictiontransient ischaemic attack

Identifiers

PMID41647687
PMCPMC12870696

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Registered trials

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