ArticleFundamental research2026
Accumulation of the spontaneous and random mutations is causative of fungal culture degeneration.
Article in Fundamental research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Parallel and comparative transcriptome and proteome provide insight into degeneration-related key candidates in Agaricus bisporus.BMC genomics · 2026Article
- Transcriptomic Data Suggest Pathways Involved in Conidiation Degeneration and Its Rejuvenate by Passage in theJournal of fungi (Basel, Switzerland) · 2026Article
- Unravelling the Potential of Fungal Division of Labour in the Laccase ProducerJournal of fungi (Basel, Switzerland) · 2025Article
- Integrated Transcriptomics and Metabolomics Provide Insight into Degeneration-Related Molecular Mechanisms ofJournal of fungi (Basel, Switzerland) · 2025Article
- Comparative transcriptomics and metabolomics provide insight into degeneration-related physiological mechanisms of Morchella importuna after long-term preservation.Microbial biotechnology · 2025Article
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Authors and funding
4 authors.
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Abstract
Filamentous fungi frequently degenerate during subculturing, which manifests as the reduction or loss of conidiation, sexuality, secondary metabolite production, and/or virulence against hosts. The underlying mechanism of spontaneous fungal degeneration is still elusive. In this study, the fluffy mycelium-type sector variants formed by three ascomycete fungi were transferred and found to show the typical features of culture degeneration. The variant cells were evidenced with the accumulation of reactive oxygen species (ROS), and the ROS-associated formation of hyphal coils. Genome resequencing of these sector cultures identified substantial random mutation sites in each variant in a trend associated with fungal reproduction style. The high bias towards transversions over transitions was similarly detected in degenerate genomes. Otherwise, a higher number of mutations were accumulated in the intergenic regions of the
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