Evidence map›Paper›PMID 41647545›Full record

ArticleFundamental research2026

Engineering of rhesus monkey pluripotent stem cells for noninvasive survey and remote control after brain allotransplantation.

Jiayi Cheng, Bowen Zhang, Wenjun Cai, Siqing Zhao, Xiaoyun Deng, Baofeng Wang, Xiaohua Zhu, Yingying Lv, Wenzhen Zhu, Xiaoqing Zhang and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Fundamental research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Jiayi ChengTranslational Research Institute of Brain and Brain-Like Intelligence, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai 200434, China.
Bowen ZhangTranslational Research Institute of Brain and Brain-Like Intelligence, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai 200434, China.
Wenjun CaiDepartment of Rehabilitation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Siqing ZhaoTranslational Research Institute of Brain and Brain-Like Intelligence, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai 200434, China.
Xiaoyun DengDepartment of Nuclear Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Baofeng WangDepartment of cerebral surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Xiaohua ZhuDepartment of Nuclear Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Yingying LvDepartment of Rehabilitation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Wenzhen ZhuDepartment of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Xiaoqing ZhangTranslational Research Institute of Brain and Brain-Like Intelligence, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai 200434, China.
Hong ChenDepartment of Rehabilitation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Ling LiuTranslational Research Institute of Brain and Brain-Like Intelligence, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai 200434, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Advanced technologies of targeted differentiation and genetic engineering in pluripotent stem cells (PSCs) offer production of purposefully designed cells for transplantation. Here, we engineer rhesus monkey PSCs (rhPSCs) to produce safe and functional neural progenitors and neurons, which could be noninvasively surveyed and controlled after brain transplantation. RhPSCs expressing hM3Dq-mCherry exhibited normal karyotype and had the ability to equally self-renew and differentiate into functional neurons as that of the mCherry expressing control. After allotransplantation into monkey prefrontal cortex, the hM3Dq-mCherry expressing rhPSC-derived cortical progenitors survived and matured gradually, which could be long-termly surveyed by [

Indexed as

BrainGenetic engineeringNonhuman primatePluripotent stem cellTransplantation

Identifiers

PMID41647545
PMCPMC12869787

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.