Evidence map›Paper›PMID 41647476›Full record

ArticleCognitive therapy and research2025

Subtypes of Severe OCD and Treatment Outcome: A Latent Profile Analysis of the Yale-Brown Obsessive-Compulsive Severity Scale.

Allen J Bailey, Meghan Schreck, Jacob A Nota, Jennie M Kuckertz, Martha J Falkenstein

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Article in Cognitive therapy and research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Allen J BaileyDivision of Alcohol, Drugs, and Addiction, McLean Hospital, Belmont, MA.
Meghan SchreckOCD Institute, McLean Hospital.
Jacob A NotaOCD Institute, McLean Hospital.
Jennie M KuckertzOCD Institute, McLean Hospital.
Martha J FalkensteinOCD Institute, McLean Hospital.

Funding

Leveraging Machine Learning Approaches to Understand Mechanisms of Exposure Therapy in Real-World SettingsR01MH135899 · NIMH · SAN DIEGO STATE UNIVERSITY · PI Jennie M Kuckertz · 2024 to 2026
$2.3M
The Role of Behavior Therapy Combined with Buprenorphine for the Treatment of Opioid Use DisorderR01DA054113 · NIDA · MCLEAN HOSPITAL · PI MCHUGH, REBECCA KATHRYN · 2022 to 2024
$1.1M
Interpretation Bias as a Mechanism of Treatment Response in OCD - Administrative SupplementK23MH126193 · NIMH · MCLEAN HOSPITAL · PI Martha J Falkenstein · 2021 to 2026
$1.0M
NIDA NIH HHS R01 DA054113NIMH NIH HHS K23 MH126193NIMH NIH HHS R01 MH135899
6 · The paper itself

Abstract

Background: The Yale-Brown Obsessive Compulsive Scale (Y-BOCS) is the gold standard measure of OCD and the most common tool to assess OCD severity and treatment outcome. Relying on Y-BOCS total scores likely to capture overall severity well, but may obscure important Methods: Participants were adults 759 (49% women) seeking partial/residential treatment for severe OCD. The sample was on average 29.81( Results: Three profiles were identified: a "Severe with Lower Resistance" Profile (69% of sample) characterized by high severity with the greatest relative effort to resist symptoms, a "Moderate" profile (25%) characterized by uniform endorsement of items in the moderate range, a "Low Compulsion" (6%) profile characterized by high mean endorsement of obsession items and low endorsement of compulsion items. The profiles varied significantly in terms of endorsement of different obsession/compulsion domains but did not vary significantly in terms of treatment outcomes as measured by changes in OCD, depression, and quality-of-life. Conclusions: Relying on Y-BOCS total score may fail to capture qualitatively different, albeit rare, presentations of OCD. However, these profiles were not predictive of treatment response.

Indexed as

classificationlatent profilelatent profile analysisobsessive compulsive disorderseveritytreatment outcometreatment responseYale-Brown Obsessive-Compulsive Severity Scale

Identifiers

PMID41647476
PMCPMC12872177

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.