ArticleJournal of biomedical optics2026
Integrated spectral and depth compensation approach for optimizing oxygen saturation and total hemoglobin estimation in photoacoustic tomography for ovarian lesion diagnosis.
Article in Journal of biomedical optics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Characterization of vascular patterns in endometrial cancer via optical resolution photoacoustic microscopy.Journal of biomedical optics · 2026Article
- Potential of photoacoustic imaging for assessing tumor perfusion in intraocular tumors and high-resolution choroidal microvascular imaging: from technical advances to clinical translation.Frontiers in oncology · 2026Review
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Authors and funding
6 authors.
Funding
Abstract
Significance: Photoacoustic tomography (PAT) holds promise for non-invasive functional imaging in ovarian cancer diagnostics. However, accurate estimation of oxygen saturation ( Aim: We aim to improve the accuracy and clinical utility of Approach: We introduce a spectral compensation strategy derived from Monte Carlo simulations and integrate it with depth-wise fluence correction to construct the proposed ISDC method. The approach has been validated using phantoms with known optical properties and applied to clinical PAT data from 82 ovarian lesions (67 benign and 15 malignant). Diagnostic performance was evaluated using logistic regression and receiver operating characteristic analysis. Results: In phantom experiments, ISDC improved Conclusions: The ISDC approach significantly enhances the quantitative accuracy and diagnostic performance of PAT by compensating for both spectral and depth fluence variations within biological tissue. These improvements support the integration of ISDC into US-PAT systems for ovarian lesion characterization and future clinical applications.
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