ArticleAvicenna journal of phytomedicine2026
Article in Avicenna journal of phytomedicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Notoginsenoside R1 Inhibits Porcine Deltacoronavirus Infection In Vitro by Restoring SERCA2-Mediated Calcium Homeostasis.Animals : an open access journal from MDPI · 2026Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: To evaluate whether Materials and Methods: C57BL/6J mice were subjected to CUMS for 7 weeks to induce depressive-like behaviors. Then PNF 1.7 or 3.4 g/kg was administered via intragastric gavage once a day for 4 consecutive weeks. After behavioral assessment, the systemic inflammation and neuroinflammation were investigated by detecting inflammatory factors in serum and brain with enzyme-linked immunosorbent assay (ELISA). The serum levels of adrenocorticotropic hormone (ACTH) and glucocorticoids (GC) were also determined. The activation of microglia and astrocyte was investigated by immunohistochemistry. The chemical components in PNF were analyzed with Ultra-high performance liquid chromatography/MS (UPLC/MS). Results: PNF 1.7 and 3.4 g/kg treatment alleviated depressive behavior in CUMS mice in various behavioral studies. In both serum and brain, PNF treatment significantly counteracted the CUMS-induced enhancement of typical pro-inflammatory factors, Tumor Necrosis Factor alpha (TNF-α), Interleukin-1β (IL-1β), and IL-6 and counteracted the CUMS-induced decrease of anti-inflammatory factorIL-10. Treatment with PNF also attenuated the CUMS-induced serum ACTH and GC elevation. Immunohistochemical analysis revealed that PNF treatment significantly reduced the number of ionized calcium-binding adapter molecule 1 (Iba-1) and glial fibrillary acidic protein (GFAP) positive cells in the brains of CUMS mice, indicating an inhibition of microglial and astrocytic activation. UPLC/MS study suggest that ginsenoside Rh1 is the main ginsenoside in the extract. Conclusion: PNF ameliorates CUMS-induced depression-like behaviors in mice, which may be mainly related to reducing neuroinflammation in the brain.
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