Evidence map›Paper›PMID 41647406›Full record

ArticleRSC advances2026

Synergistic NIR-polydopamine nanotherapy for blood-brain barrier crossing and Parkinson's disease intervention.

Xueer Xia, Jianbang Han, Meiyin Lin, Yingfeng Tu, Yue Zheng, Bin Liu, Yu Chen, Xin Li, Zirong Zhang, Shuai Han and 3 more

Abstract read
In one paragraph

Article in RSC advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Xueer XiaMedical Engineering &Engineering Medicine Innovation Center, Hangzhou International Innovation Institute, Beihang University No. 166, Shuanghongqiao Street, Yuhang District 311115 Hangzhou China sharon@buaa.edu.cn +86-13580346984.ORCID https://orcid.org/0009-0001-7233-6668
Jianbang HanDepartment of Neurology, Guangzhou First People's Hospital, The Second Affiliated Hospital of South China University of Technology Guangzhou 510000 China.
Meiyin LinDepartment of Oncology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University No. 123 Huifu Road West, Yuexiu District Guangzhou 510080 China liujianh80@126.com +86-20-18666003180.
Yingfeng TuNMPA Key Laboratory for Research and Evaluation of Drug Metabolism & Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University Guangzhou 510515 China.ORCID https://orcid.org/0000-0003-2605-0172
Yue ZhengDepartment of Gastroenterology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University Guangzhou 510080 China.
Bin LiuDepartment of Radiology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University Guangzhou 510080 China.
Yu ChenDepartment of Pathology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University Guangzhou 510080 China.
Xin LiDepartment of Oncology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University No. 123 Huifu Road West, Yuexiu District Guangzhou 510080 China liujianh80@126.com +86-20-18666003180.
Zirong ZhangDepartment of Gastroenterology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University Guangzhou 510080 China.
Shuai HanDepartment of Gastrointestinal Surgery, General Surgery Center, Zhujiang Hospital, Southern Medical University Guangzhou 510282 China.
Wenting ShangInstitute of Automation, Chinese Academy of Sciences Beijing 100190 China.
Xiazi HuangMedical Engineering &Engineering Medicine Innovation Center, Hangzhou International Innovation Institute, Beihang University No. 166, Shuanghongqiao Street, Yuhang District 311115 Hangzhou China sharon@buaa.edu.cn +86-13580346984.
Jianhua LiuDepartment of Oncology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University No. 123 Huifu Road West, Yuexiu District Guangzhou 510080 China liujianh80@126.com +86-20-18666003180.ORCID https://orcid.org/0000-0001-6538-6459

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite its clinical success, conventional deep-brain stimulation (DBS) for Parkinson's remains limited by its invasive nature. To overcome this, we engineered ZnO@polydopamine (ZnO@PDA) nanocomposites as a non-invasive neurotherapeutic platform. By leveraging rational nanostructure design, ZnO@PDA enabled reversible blood-brain barrier (BBB) opening

Identifiers

PMID41647406
PMCPMC12869858

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.