ArticleRheumatology advances in practice2026
Everyone's different: a qualitative study of patient perspectives on receiving information about methotrexate from rheumatology nurses.
Article in Rheumatology advances in practice, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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4 authors.
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Abstract
Objectives: Methotrexate (MTX) is the anchor drug for RA but because of its risk-benefit profile it needs careful education to ensure people take it safely. This study explores perspectives of people with RA receiving information provided by rheumatology nurses when starting MTX, focusing on their needs, concerns and whether expectations matched their experiences. Methods: Adults with RA participated in semi-structured qualitative interviews before and after receiving information when starting MTX. Data were analysed using reflexive thematic analysis. Results: Nineteen participants attending two rheumatology units in England shared their experiences of receiving information about MTX treatment from a rheumatology nurse. An overarching theme described the desire to receive individualised care tailored to meet specific needs and concerns against experiences of standardised information. Many participants reported not having opportunities to discuss concerns about why they should take MTX. Worries about side-effects and treatment-related harms were frequently unresolved. Recalling practical aspects of treatment and timing of blood tests was often difficult. Knowing when MTX should not be taken and acting on advice to seek medical help if unwell could be hard to understand. Lack of clarity about prescribing and monitoring added complexity and burden. Conclusion: These findings provide insights into patient experiences, illustrating unmet information needs when starting MTX to treat RA. People with RA wanted care to address their individual circumstances. A person-centred approach providing tailored information addressing individual needs and concerns offers opportunities to increase patient satisfaction and information recall, leading to improved safety, treatment adherence and patient outcomes.
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