Evidence map›Paper›PMID 41647289›Full record

ArticleRegenerative biomaterials2026

A smart nanocomposite bioactive ink for controlled siRNA delivery in calvarial mesenchymal stromal cells as a minimally invasive treatment for craniosynostosis.

Martina Salvati, Federica Tiberio, Noah Giacon, Alberto Augello, Gianpiero Tamburrini, Lorena Di Pietro, Alessia Vita, Domiziano Dario Tosi, Giordano Perini, Giorgia Canini and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Regenerative biomaterials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Identification of a Force-Induced Sox9Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Martina SalvatiUnità Operativa Complessa di Neurochirurgia Infantile, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome 00168, Italy.
Federica TiberioDipartimento Scienze della Vita e Sanità Pubblica, Università Cattolica del Sacro Cuore, Rome 00168, Italy.
Noah GiaconDipartimento di Scienze Biotecnologiche di Base, Cliniche Intensivologiche e Perioperatorie, Università Cattolica del Sacro Cuore, Rome 00168, Italy.
Alberto AugelloFondazione Policlinico Universitario A. Gemelli, IRCCS, Rome 00168, Italy.
Gianpiero TamburriniUnità Operativa Complessa di Neurochirurgia Infantile, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome 00168, Italy.
Lorena Di PietroDipartimento Scienze della Vita e Sanità Pubblica, Università Cattolica del Sacro Cuore, Rome 00168, Italy.
Alessia VitaUnità Operativa Complessa di Neurochirurgia Infantile, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome 00168, Italy.
Domiziano Dario TosiUnità Operativa Complessa di Neurochirurgia Infantile, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome 00168, Italy.
Giordano PeriniFondazione Policlinico Universitario A. Gemelli, IRCCS, Rome 00168, Italy.
Giorgia CaniniDipartimento di Scienze Biotecnologiche di Base, Cliniche Intensivologiche e Perioperatorie, Università Cattolica del Sacro Cuore, Rome 00168, Italy.
Diego SibiliaFondazione Policlinico Universitario A. Gemelli, IRCCS, Rome 00168, Italy.
Valentina PalmieriDipartimento di Neuroscienze, Università Cattolica del Sacro Cuore, Rome 00168, Italy.
Massimiliano PapiFondazione Policlinico Universitario A. Gemelli, IRCCS, Rome 00168, Italy.
Ornella ParoliniDipartimento Scienze della Vita e Sanità Pubblica, Università Cattolica del Sacro Cuore, Rome 00168, Italy.
Luca MassimiUnità Operativa Complessa di Neurochirurgia Infantile, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome 00168, Italy.
Alessandro ArcovitoFondazione Policlinico Universitario A. Gemelli, IRCCS, Rome 00168, Italy.
Wanda LattanziUnità Operativa Complessa di Neurochirurgia Infantile, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome 00168, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Craniosynostosis (CS), characterized by the premature fusion of cranial sutures, often results from aberrant activation of

Indexed as

Craniosynostosisdrug deliveryGelMA hydrogelPLGA nanoparticlessiRNA-mediated FGFR2 regulation

Identifiers

PMID41647289
PMCPMC12869795

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.