Evidence map›Paper›PMID 41647287›Full record

ArticleRegenerative biomaterials2026

Biomimetic bilayer hydrogel coating with antithrombotic and anticalcification properties for cardiovascular tissue engineering application.

Shisong Chen, Qin Li, Chao Ye, Jiajun Pan, Si Chen, Jingwen Zhou, Lei Liu, Jiajun Zhang, Zhiyun Xu, Bailing Li and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Regenerative biomaterials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Shisong ChenDepartment of Cardiovascular Surgery Laboratory, Changhai Hospital, Navy Medical University, Shanghai 200433, China.
Qin LiDepartment of Cardiovascular Surgery Laboratory, Changhai Hospital, Navy Medical University, Shanghai 200433, China.
Chao YeDepartment of Cardiovascular Surgery Laboratory, Changhai Hospital, Navy Medical University, Shanghai 200433, China.
Jiajun PanDepartment of Cardiovascular Surgery, Changhai Hospital, Navy Medical University, Shanghai 200433, China.
Si ChenDepartment of Cardiovascular Surgery, Changhai Hospital, Navy Medical University, Shanghai 200433, China.
Jingwen ZhouDepartment of Cardiovascular Surgery Laboratory, Changhai Hospital, Navy Medical University, Shanghai 200433, China.
Lei LiuDepartment of Cardiovascular Surgery Laboratory, Changhai Hospital, Navy Medical University, Shanghai 200433, China.
Jiajun ZhangDepartment of Cardiovascular Surgery, Changhai Hospital, Navy Medical University, Shanghai 200433, China.
Zhiyun XuDepartment of Cardiovascular Surgery, Changhai Hospital, Navy Medical University, Shanghai 200433, China.
Bailing LiDepartment of Cardiovascular Surgery, Changhai Hospital, Navy Medical University, Shanghai 200433, China.
Lin HanDepartment of Cardiovascular Surgery, Changhai Hospital, Navy Medical University, Shanghai 200433, China.
Xiaohong LiuDepartment of Cardiovascular Surgery Laboratory, Changhai Hospital, Navy Medical University, Shanghai 200433, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Decellularized extracellular matrix (dECM), a promising tissue engineering scaffold for cardiovascular applications, might exhibit enhanced durability when endowed with anticalcification and antithrombotic properties. Herein, we present a biomimetic bilayer hydrogel coating applied to acellular swim bladders (ASBs). First, we designed an endothelium-mimicking (HCT) hydrogel coating, comprising alternately assembled endothelial glycocalyx macromolecule hyaluronic acid, copper ions, and tannic acid. Subsequently, a hydrophilic methacrylated silk fibroin (SilMA) hydrogel was incorporated as the outer coating layer. Notably, the HCT hydrogel penetrated and anchored into the ASB matrix, forming an interpenetrating network that enhanced the biostability and mechanical properties of the ASB matrix. Additionally, the SilMA hydrogel enhanced the hydrophilicity and antifouling properties of the HCT coating.

Indexed as

anticalcificationantithrombosiscardiovascular applicationdecellularized extracellular matrixtissue engineering

Identifiers

PMID41647287
PMCPMC12869794

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.