ArticleProceedings of SPIE--the International Society for Optical Engineering2025
Determination of the point-of-first-interaction for an ultra-high-performance brain PET system with "onion ring" geometry.
Article in Proceedings of SPIE--the International Society for Optical Engineering, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
We used the Monte Carlo GATE v9, (GEANT4) simulations to model annihilation photons interactions in our novel advanced brain-PET scanner in onion-ring geometry (US Patent 20210223414) with monolithic thin LYSO slab optically coupled to SiPM arrays to assess potential improvement of point-of-first-interaction (PFI) localization determination vs. conventional system. Three 250-mm-long cylindrical systems were evaluated: (i) 3-3-3 mm slab thicknesses concentric rings; (ii) 3-3-18 mm slab thicknesses concentric rings with 7-mm air-gaps and inner diameters of 250, 270 and 290 mm, respectively; and (iii) single-ring 24-mm-thick system with 250 mm inner diameter. The brain was simulated by a sphere of radioactive (F-18) water with 170-mm diameter confined by 8-mm thick spherical bone shell. The coincidence events studied via simulations involved photo-electric absorption (PA) and first-order Compton scatter (CS) interactions happening within predefined coincidence-time-window. If the distance between CS and PA event was shorter than the detector intrinsic spatial resolution, we considered it "pseudo single" event at energy-based averaged location (P
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