ArticleFrontiers in cellular and infection microbiology2025
Age-specific vaginal microecological dysbiosis associated with HPV infection: a large-scale cross-sectional study with targeted functional sequencing validation.
Article in Frontiers in cellular and infection microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- A retrospective analysis of the correlation between vaginal microecology and high-risk HPV infection among 5727 women.BMC infectious diseases · 2026Article
- Neuraminidase-Associated Vaginal Dysbiosis Correlates with HPV Infection Across Oncogenic Risk Subtypes.Infection and drug resistance · 2026Article
- Association between vaginal microecological dysfunction and cervical lesion severity in postmenopausal women: a retrospective study.Frontiers in medicine · 2026Article
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Authors and funding
15 authors.
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Abstract
Purpose: The vaginal microecological parameters as a critical immune barrier, yet their age-dependent interaction with Human papillomavirus (HPV) infection remains poorly understood. To characterize age-dependent vaginal microbiota composition and function across the female lifespan, and to evaluate the selective impact of HPV infection on microecological stability and infectious risk. Methods: A total of 23,672 women were stratified into four age groups (18-34, 35-44, 45-55, and >55 years). Vaginal microecology was evaluated using Gram-staining, pH, hydrogen peroxide (H Results: Normal flora prevalence declined linearly with age (78.7% vs. 48.8% postmenopause, q<0.001), while microbial diversity peaked during perimenopause. HPV infection was selectively associated with increased bacterial vaginosis (BV) (41.58% vs. 36.46%, q=0.032) and sialidase activity (28.14% vs. 21.69%, q=0.002), but decreased vulvovaginal candidiasis (VVC, 10.57% vs. 15.66%, q=0.003). Functional analyses revealed HPV-driven anaerobic enrichment ( Conclusion: HPV infection selectively remodels vaginal microbiota composition and metabolic function in an age-dependent manner, with midlife women (35-44 years) representing a critical window for microbiota-based HPV prevention strategies.
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