ArticleKidney diseases (Basel, Switzerland)
Noninvasive Serum LOX: A Prognostic Signature for Fibrosis Progression and Renal Survival in IgA Nephropathy.
Article in Kidney diseases (Basel, Switzerland). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: IgA nephropathy (IgAN), the most common primary glomerulonephritis, often presents with advanced renal failure and end-stage renal disease at diagnosis. Till now, there remains a lack of reliable biomarkers for effectively assessing the progression risk of IgAN. Here, we propose lysyl oxidase (LOX), a marker of collagen cross-linking, as a potential biomarker for assessing fibrosis in IgAN. Method: After evaluating the fibrosis degree by Masson staining, measuring LOX levels in serum and kidney tissues, and collecting clinical information, we analyzed the association between LOX and renal fibrosis. Logistic regression analysis was employed to identify significant variables, which were incorporated into a nomogram and machine-learning model. Results: A total of 128 IgAN patients were enrolled in the study, of which 89 were included in the training cohort and 39 patients in the validation cohort. Serum LOX levels correlated with the area of renal fibrosis ( Conclusions: Serum LOX has the potential to predict renal fibrosis in IgAN. When combined with traditional clinical indicators, it may enhance the prediction of IgAN prognosis.
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