Evidence map›Paper›PMID 41647222›Full record

ArticleArXiv2026

CEI: A Clonal Expansion Identifier for T-cell receptor clones following SARS-CoV-2 vaccination.

Yunbei Pan, Christian Hofmann, Barbara Banbury, Harsh Patel, Stephanie A Bien, Tom Chou, Otto O Yang

Abstract readPreprint
PubMed Full text at PMC
In one paragraph

Article in ArXiv, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Yunbei PanDepartment of Computational Medicine, UCLA, 621 Charles E. Young Drive S., Los Angeles, 90095-1766, CA, USA.
Christian HofmannDepts. of Medicine and Microbiology, Immunology, and Molecular Genetics, UCLA, 615 Charles E. Young Drive S., East, Los Angeles, 90095, CA, USA.
Barbara BanburyAdaptive Biotechnologies, 1165 Eastlake Ave E, Seattle, 98109, WA, USA.
Harsh PatelAdaptive Biotechnologies, 1165 Eastlake Ave E, Seattle, 98109, WA, USA.
Stephanie A BienAdaptive Biotechnologies, 1165 Eastlake Ave E, Seattle, 98109, WA, USA.
Tom ChouDepartment of Computational Medicine, UCLA, 621 Charles E. Young Drive S., Los Angeles, 90095-1766, CA, USA.
Otto O YangDepts. of Medicine and Microbiology, Immunology, and Molecular Genetics, UCLA, 615 Charles E. Young Drive S., East, Los Angeles, 90095, CA, USA.

Funding

UCLA-CDU CFARP30AI152501 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SCOTT G KITCHEN · 2022 to 2026
$15.6M
NIAID NIH HHS P30 AI152501
6 · The paper itself

Abstract

Each T cell typically carries a specific T-cell receptor (TCR) that determines its specificity against an epitope presented by the HLA complex on a target cell. Antigenic challenge triggers the expansion of reactive cells within a diverse pool of T cells with randomly generated receptors, a process that results in epitope-driven shifts of TCR frequencies over time. Here, we analyze the effects of SARS-CoV-2 vaccination on the TCR populations in peripheral blood drawn from seven COVID-naive individuals, before vaccines were widely available. To identify SARS-CoV-2 vaccine-associated TCR sequences among the ~ 10

Indexed as

COVID-19statistical identificationT-cell activationvaccination

Identifiers

PMID41647222
PMCPMC12869421

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.