ReviewClinics in colon and rectal surgery2026
Anal Dysplasia: A Review of Pathology with Focus on Current Terminology, Pathologic Diagnosis, and Diagnostic Challenges.
Review in Clinics in colon and rectal surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
4 authors.
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Abstract
Anal cancer, although rare, has been increasing in incidence, particularly among high-risk groups such as individuals with human immunodeficiency virus (HIV) and men who have sex with men. The majority of anal cancers are squamous cell carcinomas, most of which are associated with high-risk human papillomavirus (HPV), particularly HPV16. The diagnosis of anal dysplasia requires a multifaceted approach involving clinical evaluation, cytology, high-resolution anoscopy, and histopathologic examination. This review highlights the current understanding of the pathogenesis, diagnostic challenges, and management of HPV-related anal dysplasia and cancer. The evolution of diagnostic terminology, notably the adoption of the two-tiered classification system for HPV-related anal squamous lesions, has improved the consistency of diagnosis. Early detection of anal dysplasia is crucial for effective treatment, particularly in high-risk populations. While anal cytology is a key screening tool, its low specificity necessitates confirmatory diagnosis through anal biopsy with the aid of ancillary tests, including p16 and K
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