SynthesisFrontiers in medicine2025
Effectiveness of melatonin supplementation for improving sleep quality and disease severity in children with atopic dermatitis: a systematic review and meta-analysis.
Synthesis in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Itching, Ionic Channels, Immune System, Magnesium and Antioxidants.Clinical, cosmetic and investigational dermatology · 2026Review
Corrections and comments
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Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Atopic dermatitis (AD) is a chronic inflammatory skin condition causing pruritus, leading to sleep disturbance and poor quality of life, particularly in children. Effective adjunctive treatments addressing these issues are crucially needed. Objective: To evaluate the effects of melatonin supplementation on sleep quality and disease severity in children with atopic dermatitis through a systematic review and meta-analysis. Materials and methods: A systematic review with meta-analysis was conducted using three randomized controlled trials (RCTs). Eligible studies compared melatonin supplementation (3-6 mg/day) to placebo. Data was analyzed using a random-effects model with mean differences and standardized mean differences reported at 95% confidence intervals (CIs). Risk of bias was assessed using the Cochrane Risk of Bias Tool 2.0, and heterogeneity was evaluated using I Results: Melatonin significantly reduced sleep onset latency with a pooled standard mean difference of -0.63 (95% CI: -1.00 to -0.26, Conclusion: Melatonin effectively improves sleep initiation in children with atopic dermatitis and may have modest effects on clinician-rated signs; the clinical importance remains uncertain. It appears safe, but further long-term studies are needed. Systematic review registration: https://www.crd.york.ac.uk/PROSPERO/view/CRD42023439385.
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Registered trials
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