Evidence map›Paper›PMID 41646981›Full record

ArticleFrontiers in immunology2025

The impact of STING signaling on myeloid cells highlights macrophages as the major player in controlling

Kívia Q de Andrade, Nina M G P de Queiroz, Fábio Mambelli, Fábio V Marinho, Marcelo P Amaral, Joao Gustavo P Amarante-Mendes, Glen Barber, Sérgio C Oliveira

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. A Putative Multicopper Oxidase Encoded byInternational journal of molecular sciences · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Kívia Q de AndradeDepartment of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, SP, Brazil.
Nina M G P de QueirozDepartment of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, SP, Brazil.
Fábio MambelliDepartment of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, SP, Brazil.
Fábio V MarinhoDepartment of Biochemistry and Immunology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
Marcelo P AmaralDepartment of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, SP, Brazil.
Joao Gustavo P Amarante-MendesDepartment of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, SP, Brazil.
Glen BarberCenter for Innate Immunity and Inflammation, Pelotonia Institute for Immuno-oncology, the James Comprehensive Cancer Center, Department of Surgery, Ohio State University, Columbus, OH, United States.
Sérgio C OliveiraDepartment of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, SP, Brazil.

Funding

Brucella survival strategy requires endoplasmic reticulum restructuring and interferes with innate immunityR01AI116453 · NIAID · FOUNDATION FOR RESEARCH DEVELOPMENT · PI BARBER, GLEN N, OLIVEIRA, SERGIO C · 2016 to 2025
$1.4M
NIAID NIH HHS R01 AI116453
6 · The paper itself

Abstract

Introduction: Brucellosis, caused by Methods: Therefore, we used conditional knockout animals for STING in dendritic cells (CD11c-SKO) and in macrophages (LysM-SKO). WT, LysM-SKO and CD11c-SKO mice were infected with 1×10 Results and Discussion: Infected LysM-SKO mice, but not SKO-CD11c, showed an increase in CFU compared to infected WT animals.

Indexed as

Brucella abortusBrucellosisMacrophagesMembrane ProteinsMyeloid CellsSignal TransductionAnimalscGAS-STING Signaling PathwayCytokinesDendritic CellsFemaleImmunity, InnateInflammasomesMiceMice, Inbred C57BLMice, KnockoutCytokinesInflammasomesMembrane ProteinsSting1 protein, mouseSTING ProteinBrucella abortusdendritic cellsinflammasomemacrophagesSTING

Identifiers

PMID41646981
PMCPMC12868222

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.