Evidence map›Paper›PMID 41646965›Full record

ArticleFrontiers in immunology2025

CREG1 restricts ALV-J replication via the mitochondrial dysfunction-driven activation of innate immunity and apoptosis.

Qihong Zhang, Meihuizi Wang, Ming Pan, Junliang Xia, Tao Xu, Wen Luo, Xiquan Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Qihong ZhangState Key Laboratory of Swine and Poultry Breeding Industry, and Guangdong Laboratory for Lingnan Modern Agriculture, Guangzhou, China.
Meihuizi WangState Key Laboratory of Swine and Poultry Breeding Industry, and Guangdong Laboratory for Lingnan Modern Agriculture, Guangzhou, China.
Ming PanState Key Laboratory of Swine and Poultry Breeding Industry, and Guangdong Laboratory for Lingnan Modern Agriculture, Guangzhou, China.
Junliang XiaState Key Laboratory of Swine and Poultry Breeding Industry, and Guangdong Laboratory for Lingnan Modern Agriculture, Guangzhou, China.
Tao XuState Key Laboratory of Swine and Poultry Breeding Industry, and Guangdong Laboratory for Lingnan Modern Agriculture, Guangzhou, China.
Wen LuoState Key Laboratory of Swine and Poultry Breeding Industry, and Guangdong Laboratory for Lingnan Modern Agriculture, Guangzhou, China.
Xiquan ZhangState Key Laboratory of Swine and Poultry Breeding Industry, and Guangdong Laboratory for Lingnan Modern Agriculture, Guangzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Host antiviral defense relies on key regulatory genes that coordinate immune signaling and cellular homeostasis, yet their roles in J subgroup avian leukosis virus (ALV-J) infection remain poorly defined. Here, we identify cellular repressor of E1A-stimulated genes 1 ( Methods: In this study, transcriptomic analysis and RT-qPCR revealed that the expression of Results: Overexpression of Conclusions: Overall, we identify

Indexed as

ApoptosisAvian LeukosisAvian Leukosis VirusAvian ProteinsImmunity, InnateMitochondriaPoultry DiseasesVirus ReplicationAnimalsChickensMembrane Potential, MitochondrialAvian ProteinsALV-JapoptosisCREG1innate immunitymitochondial dysfunction

Identifiers

PMID41646965
PMCPMC12867876

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.