ArticleFrontiers in pharmacology2025
Ginsenoside Rk1 alleviates lipopolysaccharide (LPS)-induced cognitive impairment by modulating synaptic plasticity.
Article in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: This study aimed to comprehensively investigate the therapeutic effects of ginsenoside Rk1 on LPS-induced cognitive impairment and elucidate its underlying mechanisms, with a particular focus on synaptic plasticity and related signaling pathways, thereby providing robust theoretical and experimental support for its neuroprotective application. Research Methods: Network pharmacology identified potential therapeutic targets and pathways of ginsenoside Rk1 relevant to inflammation-induced cognitive impairment, and molecular docking assessed its binding affinity with key predicted proteins. Results: Network pharmacology successfully identified significant overlaps between ginsenoside Rk1 targets and pathways associated with inflammation and cognitive impairment, prominently featuring the PI3K/Akt pathway. Molecular docking simulations confirmed strong binding affinities between ginsenoside Rk1 and key proteins in this pathway. Conclusion: This study provides compelling evidence that ginsenoside Rk1 effectively alleviates LPS-induced cognitive dysfunction by ameliorating neuroinflammation and significantly enhancing synaptic plasticity. The mechanistic insights suggest that these neuroprotective effects are mediated, at least in part, through the modulation of the PI3K/Akt signaling pathway.
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