ArticleMolecular therapy. Nucleic acids2026
2'-Ribose-modified nucleotides: A strategy for reducing off-target effects of oligonucleotide drugs.
Article in Molecular therapy. Nucleic acids, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Necessary chemical modifications can enhance the metabolic stability and therapeutic efficacy of oligonucleotide-based drugs. Herein, a series of mononucleotides with different functional group modifications at the ribose 2'-position were designed and synthesized for reducing off-target effects of oligonucleotide drugs. After incorporating them into the antisense strand of small interfering RNAs (siRNAs), we assessed their biophysical and biological properties. The results revealed that, following the substitution of the conventional 2'-O-methyl or 2'-O-fluoro ribose modifications with our newly designed functional groups, although the thermal stability of the duplexes decreased, the
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