ArticleEuropean heart journal. Imaging methods and practice2026
Dynamic assessment of global longitudinal strain after isometric exercise to predict functionally significant coronary lesion.
Article in European heart journal. Imaging methods and practice, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Sensitivity and specificity of speckle tracking echocardiography for coronary artery disease: a systematic review and meta-analysis.Frontiers in cardiovascular medicine · 2026Pooled it
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Authors and funding
7 authors.
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Abstract
Aims: There is still a wide debate regarding the management of patients with chronic coronary syndrome, the choice of optimal non-invasive stress test, and the decision for coronary revascularization. Evidence has accumulated demonstrating the utility of global longitudinal strain (GLS) as a predictor of significant coronary disease. To evaluate the application of speckle tracking during resting echocardiography and after isometric loading with the hand-grip test, and to compare GLS parameters with fractional flow reserve (FFR). Methods and results: Patients with known CCS who underwent angiography with evidence of coronary stenosis >40%<90% and were referred for functional assessment were enrolled in this study. Patients with previous MI, depressed LV systolic function, and poor acoustic window were excluded. Patients underwent a standard echocardiography with recordings suitable for LV speckle tracking. Subsequently, a dynamic hand-grip test was performed for 3 min, then the same images were captured. Global longitudinal strain was calculated at rest (rGLS), under stress conditions (sGLS), as well as the absolute difference between the two measurements - ΔGLS. Then, patients underwent invasive functional assessment with measurement of the FFR of the coronary lesion. Correlation analysis of myocardial strain parameters and FFR was performed. A total of 106 patients were included in the study. The mean rGLS was -18.5 ± 1.8, sGLS: -19.1 ± 2.0 and ΔGLS: 0.62 ± 1.4. In total, 44% of patients had a functionally significant coronary lesion when assessed with FFR. There was a statistically significant correlation between ΔGLS and FFR values, r = 0.660, Conclusion: Dynamic GLS during isometric hand-grip exercise is a feasible method for functional assessment in patients with chronic coronary syndrome.
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