ReviewFrontiers in cell and developmental biology2026
Evolution and mechanistic insights of platelet-derived products in temporomandibular joint regeneration.
Review in Frontiers in cell and developmental biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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9 authors.
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Abstract
Temporomandibular disorders (TMDs) and end-stage osteoarthritis are among the most common disabling diseases of the oral and maxillofacial region. Due to its unique fibrocartilaginous structure and limited vascularization, the temporomandibular joint (TMJ) possesses an extremely limited intrinsic regenerative capacity. Unlike conventional treatments that predominantly address symptoms, autologous platelet-derived products (APDs), such as platelet-rich plasma, platelet-rich fibrin, and concentrated growth factors, have been increasingly investigated for their biological roles in TMJ repair by mimicking natural healing mechanisms. This review summarizes the technical evolution of APDs and elucidates the molecular mechanisms promoting TMJ regeneration. Specifically, it discusses how APDs modulate the TMJ microenvironment by driving mesenchymal stem cell proliferation, directing chondrogenic differentiation, and resolving inflammation through immunomodulatory cascades. In addition, this review discusses the relevance of rheological properties for stage-specific clinical application and outlines translational considerations for the use of APDs in the management of TMDs.
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