Evidence map›Paper›PMID 41646842›Full record

SynthesisFrontiers in immunology2026

Nanoparticles in influenza research: a bibliometric analysis of global trends (2005 - 2025).

Yezi Zhang, Xi Lin, Lingling Wen, Jiaona Zhang, Jian Lin, Xinghua Liu, Yuxiang Liu, Siyuan Xu, Xingdong Lin, Zhizhun Mo

Abstract readReviewSystematic Review
In one paragraph

Synthesis in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yezi Zhang *The Third Clinical Medical College of Guangzhou University of Chinese Medicine, Guangzhou, China.
Xi Lin *The Third Clinical Medical College of Guangzhou University of Chinese Medicine, Guangzhou, China.
Lingling WenShenzhen Traditional Chinese Medicine Hospital, The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen, China.
Jiaona ZhangGuangzhou University of Chinese Medicine Science and Technology Innovation Center, Guangzhou, China.
Jian LinThe Third Clinical Medical College of Guangzhou University of Chinese Medicine, Guangzhou, China.
Xinghua LiuThe Third Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.
Yuxiang LiuShenzhen Traditional Chinese Medicine Hospital, The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen, China.
Siyuan XuThe Third Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.
Xingdong LinThe Third Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.
Zhizhun MoShenzhen Traditional Chinese Medicine Hospital, The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Influenza viruses cause approximately 3 to 5 million severe cases and tens of thousands of deaths globally each year, posing a continuous threat to public health. Nanoparticles with superior biocompatibility, combined with traditional Chinese herbal medicine could offer promising avenues to enhance therapeutic efficacy, improve targeting precision, and address multidrug resistance. This study aims to provide a comprehensive review of the current status and future directions of nanoparticle applications in influenza research, thereby providing more effective and convenient solutions for influenza prevention and control. Methods: A publication search was performed using Web of Science Core Collection, Scopus, and PubMed from 2005 to 2025 to improve the completeness of publications collection. Bibliometric analyses performed using Bibliometrix, CiteSpace, and VOSviewer software to compensate for the differences in their respective algorithms. The analysis by evaluating publication quantity, Citation Counts, and Co-authorship status to find the core institutions, journals, and key authors. Explore the research hotspots of nanoparticles and influenza through keyword analysis. Result: A total of 3,478 relevant publications were identified. The United States and China were the primary contributors in terms of publication volume, with the Chinese Academy of Sciences leading in institutional contributions. Vaccines emerged as the top-performing journal in this field. Masaru Kanekiyo's article had the highest local citation count, and he was identified as the author with the greatest individual contribution. Keyword analysis revealed that optimizing delivery systems and advancing vaccine development are central research priorities. Notably, bibliometric analysis revealed that besides metal-based nanoparticles, viral-like particles, polymer nanoparticles, and lipid nanoparticles in the field of delivery system research, herbal small-molecule nanoparticle delivery system has garnered significant attention due to the promise for future clinical applications. Conclusion: Research on nanoparticles in influenza is rapidly advancing, with a primary focus on their application in vaccine development and delivery optimization. The field is also exploring nanoparticles from various sources. Future research should bridge basic mechanistic studies with clinical applications to enhance their impact.

Indexed as

Biomedical ResearchInfluenza, HumanInfluenza VaccinesNanoparticlesAnimalsAntiviral AgentsBibliometricsHumansAntiviral AgentsInfluenza VaccinesbibliometricCiteSpaceinfluenzananoparticlesVOSviewer

Identifiers

PMID41646842
PMCPMC12867802

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.