Evidence map›Paper›PMID 41646795›Full record

ArticlemedRxiv : the preprint server for health sciences2026

A Randomized Double-Blind Placebo-Controlled Phase I/II Clinical Trial of a Human Papillomavirus Therapeutic Vaccine, PepCan, for Reducing Head and Neck Cancer Recurrence.

Emily Bivens, Omar Atiq, Teresa Evans, Milan Bimali, Ginger Brown, Jasmine Crane, Nadia Darwish, Jennifer L Faulkner, Rangaswamy Govindarajan, Aaron Johnson and 12 more

Registry-linked trialAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03821272 (A Phase I/II Clinical Trial of PepCan in Head and Neck Cancer Patients in Remission to Reduce Recurrence Regardless of HPV Status), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03821272 phase1 / phase2completednot on this map

A Phase I/II Clinical Trial of PepCan in Head and Neck Cancer Patients in Remission to Reduce Recurrence Regardless of HPV Status

TypeinterventionalSponsorUniversity of ArkansasRan2019 to 2025Enrolled17ConditionsHead and Neck CancerArmsPepCan, Placebo
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

22 authors.

Emily BivensDepartment of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Omar AtiqInternal Medicine, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Teresa EvansDepartment of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Milan BimaliBiostatistics, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Ginger BrownCollege of Medicine & Winthrop P. Rockefeller Cancer Institute, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Jasmine CraneDepartment of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Nadia DarwishDepartment of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Jennifer L FaulknerCollege of Medicine & Winthrop P. Rockefeller Cancer Institute, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Rangaswamy GovindarajanInternal Medicine, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Aaron JohnsonCollege of Medicine & Winthrop P. Rockefeller Cancer Institute, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Alongkorn KurilungBiomedical Informatics, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Oxana LazarenkoDepartment of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Yong-Chen LuDepartment of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Keanna MarshDepartment of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Mauricio MorenoOtolaryngology - Head and Neck Surgery, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Intawat NookaewBiomedical Informatics, University of Arkansas for Medical Sciences, Little Rock, AR, USA.ORCID 0000-0001-8901-1088
Michael RobesonBiomedical Informatics, University of Arkansas for Medical Sciences, Little Rock, AR, USA.ORCID 0000-0001-7119-6301
Jumin SundeOtolaryngology - Head and Neck Surgery, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
David UsseryBiomedical Informatics, University of Arkansas for Medical Sciences, Little Rock, AR, USA.ORCID 0000-0003-3632-5512
Emre VuralOtolaryngology - Head and Neck Surgery, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Mindy WilmanCollege of Medicine & Winthrop P. Rockefeller Cancer Institute, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Mayumi NakagawaDepartment of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.

Funding

Expanding Translational Research in ArkansasUL1TR003107 · NCATS · UNIV OF ARKANSAS FOR MED SCIS · PI JAMES, LAURA P · 2019 to 2023
$21.6M
Understanding and Enhancing T-Cell Responses to High Risk Human Papillomaviruses-RenewalR01CA143130 · NCI · UNIV OF ARKANSAS FOR MED SCIS · PI NAKAGAWA, MAYUMI · 2010 to 2025
$10.0M
NCATS NIH HHS UL1 TR003107NCI NIH HHS R01 CA143130
6 · The paper itself

Abstract

Objectives: Head and neck cancer (HNC) has a high recurrence rate. Safety and effectiveness of PepCan in reducing recurrence for HNC patients were assessed. Methods and analysis: PepCan consists of four human papillomavirus 16 (HPV 16) E6 peptides and a Results: Seventeen patients were enrolled. The most common adverse events were grades 1 and 2 injection site reactions, and they occurred more frequently in the PepCan group ( Conclusions: PepCan is safe although DLT can occur after multiple injections of PepCan. PepCan does not seem to be effective in reducing recurrence; however, the results are inconclusive given the small patient numbers. Trial registration number: NCT03821272.

Indexed as

adjuvanthead and neck cancerhuman papillomavirustherapeutic vaccine

Identifiers

PMID41646795
PMCPMC12870620

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.