Evidence map›Paper›PMID 41646792›Full record

ArticlemedRxiv : the preprint server for health sciences2026

Longitudinal clinical proteomics reveals pneumonia type-specific protein biomarkers and autoantibodies.

Anna Semenova, Taylor A Poor, Johannes B Müller-Reif, Sai Rama Sridatta Prakki, Phillip Geyer, Martin Mück-Häusl, Lesca M Holdt, Daniel Teupser, Matthias Mann, Ali Ö Yildirim and 6 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

Anna SemenovaResearch Unit for Precision Regenerative Medicine, Helmholtz Munich, Comprehensive Pneumology Center (CPC), Member of the German Center for Lung Research (DZL), Munich, Germany.
Taylor A PoorDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, USA.
Johannes B Müller-ReifMax Planck Institute of Biochemistry, Department of Proteomics and Signal Transduction, Martinsried, Germany.
Sai Rama Sridatta PrakkiResearch Unit for Precision Regenerative Medicine, Helmholtz Munich, Comprehensive Pneumology Center (CPC), Member of the German Center for Lung Research (DZL), Munich, Germany.
Phillip GeyerMax Planck Institute of Biochemistry, Department of Proteomics and Signal Transduction, Martinsried, Germany.
Martin Mück-HäuslResearch Unit for Precision Regenerative Medicine, Helmholtz Munich, Comprehensive Pneumology Center (CPC), Member of the German Center for Lung Research (DZL), Munich, Germany.
Lesca M HoldtInstitute of Laboratory Medicine, University Hospital, LMU Munich, Munich, Germany.
Daniel TeupserInstitute of Laboratory Medicine, University Hospital, LMU Munich, Munich, Germany.
Matthias MannMax Planck Institute of Biochemistry, Department of Proteomics and Signal Transduction, Martinsried, Germany.
Ali Ö YildirimInstitute of Lung Health and Immunity, Helmholtz Munich, Comprehensive Pneumology Center (CPC), Member of the German Center for Lung Research (DZL), Munich, Germany.
Richard G WunderinkDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, USA.
Alexander V MisharinDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, USA.
Ben D SingerDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, USA.
G R Scott BudingerDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, USA.
Theodore S KapellosInstitute of Lung Health and Immunity, Helmholtz Munich, Comprehensive Pneumology Center (CPC), Member of the German Center for Lung Research (DZL), Munich, Germany.
Herbert B SchillerResearch Unit for Precision Regenerative Medicine, Helmholtz Munich, Comprehensive Pneumology Center (CPC), Member of the German Center for Lung Research (DZL), Munich, Germany.

Funding

Tissue resident macrophages regulate proteostasis in the aging lungP01AG049665 · NIA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI NAVDEEP S CHANDEL · 2015 to 2026
$26.9M
Technology CoreU19AI135964 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Benjamin David Singer · 2018 to 2026
$24.7M
The Cell Phenotyping and Mouse CoreP01HL154998 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI KAREN M RIDGE · 2021 to 2026
$18.9M
Midwest Murine-Tissue Mapping Center (MM-TMC)U54AG079754 · NIA · UNIVERSITY OF MINNESOTA · PI GR Scott Budinger, Sundeep Khosla · 2022 to 2026
$11.5M
Synergistic roles of lung autoantibodies, donor nonclassical monocytes and recipient classical monocytes in mediating primary graft dysfunctionP01HL169188 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Ankit Bharat · 2024 to 2026
$11.1M
The Neu-Lung Consortium: Neutrophilic Mechanisms of Inflammation, Injury, and Repair in Lung and Airways DiseasesU19AI181102 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Stephanie Caroline Eisenbarth, Alexander Misharin · 2024 to 2026
$9.3M
Role of spleen educated monocytes in mediating ischemia-reperfusion injury followinglung transplant surgeryR01HL147575 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Ankit Bharat, GR Scott Budinger · 2019 to 2026
$5.5M
Pathogenesis of lung injury mediated by lung-restricted antibodiesR01HL147290 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Ankit Bharat, GR Scott Budinger · 2019 to 2026
$5.2M
CRITICAL: Collaborative Resource for Intensive care Translational science, Informatics, Comprehensive Analytics, and LearningU01TR003528 · NCATS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI CIMINO, JAMES J, LUO, YUAN · 2021 to 2024
$4.9M
Mechanisms of regulatory T cell-mediated recovery from severe viral pneumoniaR01HL149883 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Benjamin David Singer · 2020 to 2026
$4.1M
Systems-based pharmacologic modelling to elucidate beta-lactam clinical pharmacodynamics and define optimal dosing regimens in severe pneumoniaR01AI158530 · NIAID · MIDWESTERN UNIVERSITY · PI Nathaniel James Rhodes · 2022 to 2026
$3.4M
Monocyte-derived alveolar macrophage drives inflammatory response to lung ozone exposureR01ES034350 · NIEHS · DUKE UNIVERSITY · PI Alexander Misharin, Robert Matthew Tighe · 2022 to 2026
$3.0M
CSRD VA I01 CX001777NCATS NIH HHS U01 TR003528NHLBI NIH HHS P01 HL154998NHLBI NIH HHS P01 HL169188NHLBI NIH HHS R01 HL147290NHLBI NIH HHS R01 HL147575NHLBI NIH HHS R01 HL149883NHLBI NIH HHS R01 HL153122NHLBI NIH HHS R01 HL153312NHLBI NIH HHS R01 HL158139NIAID NIH HHS R01 AI158530NIAID NIH HHS U19 AI135964NIAID NIH HHS U19 AI181102NIA NIH HHS P01 AG049665NIA NIH HHS R21 AG075423NIA NIH HHS U54 AG079754NIEHS NIH HHS R01 ES034350
6 · The paper itself

Abstract

Community-acquired pneumonia is a major cause of morbidity and mortality globally. Specific molecular endotypes are currently not well defined and different viral or bacterial pathogens may trigger specific host responses and pathogenic mechanisms. We performed longitudinal proteomic profiling of bronchoalveolar lavage fluid and plasma from bacterial, influenza and SARS-COV-2 driven pneumonia. Our analysis revealed highly pneumonia type specific proteomic signatures, including COVID-19 specific antibodies locally produced in the lung. These antibodies showed biased immunoglobulin V-domain usage, linked to a

Identifiers

PMID41646792
PMCPMC12870487

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.