Evidence map›Paper›PMID 41646788›Full record

ArticlemedRxiv : the preprint server for health sciences2026

A Multi-Mineral Intervention Improves Intestinal Permeability in Patients with Ulcerative Colitis: Results from a 90-Day Pilot Trial.

Muhammad N Aslam, Danielle Kim Turgeon, Shannon McClintock, Ron Allen, Ananda Sen, James Varani

Registry-linked trialAbstract readPreprint
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04855799 (Direct Measurement of Gastrointestinal Permeability Change in Response to Aquamin®), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04855799 phase2completednot on this map

Direct Measurement of Gastrointestinal Permeability Change in Response to Aquamin®

TypeinterventionalSponsorJames VaraniRan2021 to 2024Enrolled35ConditionsUlcerative Colitis, Healthy, Irritable Bowel Syndrome With DiarrheaArmsAquamin
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Danielle Kim Turgeon
Shannon McClintock
Ron Allen
Ananda Sen
James Varani

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Previous studies have shown that Aquamin Methods: Subjects with mild or in remission ulcerative colitis (UC) and healthy controls were enrolled in an open-label trial and received Aquamin Results: In this pilot study ( NCT04855799 ), which included UC patients and healthy controls (n = 8 per group), baseline urine mannitol levels in the 0-2 h sample were 54% higher in UC patients compared to healthy subjects (p = 0.006). Following 90 days of Aquamin Conclusion: These results provide preliminary evidence that Aquamin Summary: Aquamin

Identifiers

PMID41646788
PMCPMC12870605

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.