Evidence map›Paper›PMID 41646764›Full record

ArticlemedRxiv : the preprint server for health sciences2026

Empirical limitations of current low-intensity focused ultrasound simulation platforms.

Sierra D Brandts, Brooke R Staveland, Ananya Madhusudhan, Ryan T Ash, Tommaso Di Ianni, Leo P Sugrue, Andrew D Krystal, Khaled Moussawi

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Sierra D BrandtsDepartment of Neurology, University of California, San Francisco, 94158, USA.
Brooke R StavelandDepartment of Neurology, University of California, San Francisco, 94158, USA.ORCID 0000-0001-8002-2821
Ananya MadhusudhanDepartment of Neurology, University of California, San Francisco, 94158, USA.
Ryan T AshDepartment of Psychiatry, University of California, San Francisco, 94158, USA.
Tommaso Di IanniDepartment of Psychiatry, University of California, San Francisco, 94158, USA.
Leo P SugrueDepartment of Radiology, University of California, San Francisco, 94158, USA.
Andrew D KrystalDepartment of Psychiatry, University of California, San Francisco, 94158, USA.
Khaled MoussawiDepartment of Neurology, University of California, San Francisco, 94158, USA.

Funding

Modulating ventral striatal activity and connectivity with transcranial focused ultrasound as a putative novel intervention for cocaine use disorderUG3DA060431 · NIDA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FERRARELLI, FABIO, MOUSSAWI, KHALED · 2024 to 2025
$1.4M
Modulating ventral striatal activity and connectivity with transcranial focused ultrasound as a putative novel intervention for cocaine use disorderUH3DA060431 · NIDA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Fabio Ferrarelli, KHALED MOUSSAWI · 2026 to 2026
$972k
NIDA NIH HHS UG3 DA060431NIDA NIH HHS UH3 DA060431
6 · The paper itself

Abstract

Transcranial low-intensity focused ultrasound (LIFU) is an emerging tool for noninvasive neuromodulation, with potential therapeutic applications across a range of neuropsychiatric disorders. As the field advances toward clinical translation, individualized simulations of sonication parameters are critical for estimating dosing to ensure safety, efficacy, and reproducibility. Currently,

Indexed as

BabelBrainBrainsightfocused ultrasoundk-PlanLIFUpseudo-CT

Identifiers

PMID41646764
PMCPMC12870687

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.