Evidence map›Paper›PMID 41646756›Full record

ArticlemedRxiv : the preprint server for health sciences2026

Lack of genetic evidence for a role of SLC25A46 in alpha-synucleinopathies.

Han Yu, Sitki Cem Parlar, Konstantin Senkevich, Emma N Somerville, Zhao Zhang, Lang Liu, Meron Teferra, Jamil Ahmad, Farnaz Asayesh, Guy A Rouleau and 1 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Han YuDepartment of Quantitative Life Science, McGill University, Montréal, QC, Canada.
Sitki Cem ParlarThe Neuro (Montreal Neurological Institute-Hospital), McGill University, Montréal, QC, Canada.
Konstantin SenkevichThe Neuro (Montreal Neurological Institute-Hospital), McGill University, Montréal, QC, Canada.
Emma N SomervilleThe Neuro (Montreal Neurological Institute-Hospital), McGill University, Montréal, QC, Canada.
Zhao ZhangThe Neuro (Montreal Neurological Institute-Hospital), McGill University, Montréal, QC, Canada.
Lang LiuThe Neuro (Montreal Neurological Institute-Hospital), McGill University, Montréal, QC, Canada.
Meron TeferraThe Neuro (Montreal Neurological Institute-Hospital), McGill University, Montréal, QC, Canada.
Jamil AhmadThe Neuro (Montreal Neurological Institute-Hospital), McGill University, Montréal, QC, Canada.
Farnaz AsayeshThe Neuro (Montreal Neurological Institute-Hospital), McGill University, Montréal, QC, Canada.
Guy A RouleauThe Neuro (Montreal Neurological Institute-Hospital), McGill University, Montréal, QC, Canada.
Ziv Gan-OrDepartment of Quantitative Life Science, McGill University, Montréal, QC, Canada.

Funding

Genetic characterization of atypical parkinsonismZIANS003154 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI SCHOLZ, SONJA · 2016 to 2025
$15.4M
Genome sequencing of Lewy Body Dementia and Frontotemporal Dementia: a public resource for the study of Alzheimers disease and related dementiasZIAAG000935 · NIA · NATIONAL INSTITUTE ON AGING · PI TRAYNOR, BRYAN · 2017 to 2025
$771k
Intramural NIH HHS ZIA AG000935Intramural NIH HHS ZIA NS003154
6 · The paper itself

Abstract

Background: The Objective: To assess whether Methods: We examined common variants using four representative PD genome-wide association studies (GWAS) and an RBD GWAS and applied Summary-data-based Mendelian Randomization (SMR) to evaluate whether genetically regulated expression of Results: No associations were observed between Conclusion:

Indexed as

Dementia with Lewy Bodies (DLB)genetic association studyParkinson’s disease (PD)REM sleep behavior disorder (RBD)SLC25A46

Identifiers

PMID41646756
PMCPMC12870644

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.