ArticlemedRxiv : the preprint server for health sciences2026
Determinants of the plasma metabolome: cross-sectional and longitudinal associations over 6 years in the NESDA cohort.
Article in medRxiv : the preprint server for health sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The plasma metabolome represents a valuable molecular readout of a person's physiological state, yet its relation to health, stress and lifestyle remains underexplored collectively. Here, we conducted an untargeted metabolomics analysis using 3804 paired samples from 1902 participants of the Netherlands Study of Depression and Anxiety at baseline and 6-year follow-up, quantifying 680 plasma metabolites. We characterised five metabolome profiles using principal component analysis, three with distinct biochemical enrichments related to transmembrane transport, sphingolipid and amino acid metabolism. Metabolite levels showed moderate intrapersonal correlation between baseline and 6-year follow-up (ICC
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