Evidence map›Paper›PMID 41646731›Full record

ArticlemedRxiv : the preprint server for health sciences2026

Age-dependent Genetic Risk in Pulmonary Fibrosis Patients and Relatives.

David Zhang, Chad A Newton, Imre Noth, Fernando J Martinez, Ganesh Raghu, Atlas Khan, Chen Wang, Matthew Moll, Michael H Cho, Columbia Genomics Consortium and 2 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

David ZhangDivision of Pulmonary, Allergy, and Critical Care, Department of Medicine, Columbia University Irving Medical Center, New York, NY.ORCID 0000-0002-2983-9796
Chad A NewtonDivision of Pulmonary and Critical Care, Department of Medicine, University of Texas Southwestern Medical Center, Dallas, TX.ORCID 0000-0001-5256-9029
Imre NothDivision of Pulmonary and Critical Care, Department of Medicine, University of Virginia, Charlottesville, VA.
Fernando J MartinezDivision of Pulmonary, Allergy, and Critical Care, Department of Medicine, University of Massachusetts, Worcester, MA.
Ganesh RaghuDivision of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, University of Washington Medical Center, Seattle, WA.
Atlas KhanDivision of Nephrology, Department of Medicine, Columbia University Irving Medical Center, New York, NY.
Chen WangDivision of Nephrology, Department of Medicine, Columbia University Irving Medical Center, New York, NY.
Matthew MollDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Mass General Brigham, Boston, MA.
Michael H ChoDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Mass General Brigham, Boston, MA.ORCID 0000-0002-4907-1657
Columbia Genomics Consortium
Krzysztof KirylukDivision of Nephrology, Department of Medicine, Columbia University Irving Medical Center, New York, NY.
Christine Kim GarciaDivision of Pulmonary, Allergy, and Critical Care, Department of Medicine, Columbia University Irving Medical Center, New York, NY.

Funding

Pulmonary Fibrosis and Telomerase DysfunctionR01HL093096 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI GARCIA, CHRISTINE KIM · 2009 to 2024
$6.9M
The Prognostic and Predictive Impact of Telomere Length in Fibrotic Interstitial Lung DiseaseR01HL176839 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI Chad Alan Newton · 2025 to 2026
$1.5M
Multi-omic profiling of IPF endotypesK08HL169926 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Da Zhang · 2024 to 2026
$498k
NHLBI NIH HHS K08 HL169926NHLBI NIH HHS R01 HL093096NHLBI NIH HHS R01 HL176839
6 · The paper itself

Abstract

Rationale: Idiopathic pulmonary fibrosis (IPF) is an age-related disorder with common and rare genetic risk factors. It is unknown if the effects of PF genetic risk factors differ by chronologic age. Objectives: To assess age-specific effects of genetic risk factors in PF patients and their relatives. Methods: We identified common and rare genetic risk factors using a Columbia whole genome sequencing (WGS) cohort (777 IPF, 2905 controls) and replicated findings using Trans-Omics for Precision Medicine (TOPMed, 1148 IPF, 5202 controls). We assessed age-stratified genetic risk of IPF and assessed for interaction with age across a range of cutoffs. We analyzed 313 FPF pedigrees and compared age-specific prevalence of interstitial lung disease in relatives stratified by proband genetic risk factors. Measurements and Main Results: Adjusted odds of disease from Conclusions: Age modifies the effects of genetic risk factors in IPF. Rare variants confer greater risk in younger individuals whereas the

Identifiers

PMID41646731
PMCPMC12870627

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.