Evidence map›Paper›PMID 41646675›Full record

ArticlemedRxiv : the preprint server for health sciences2026

Proteomic biomarkers of cognitive function,

Hannah M Smith, Joanna E Moodie, Gail Davies, Anne Richmond, Josephine A Robertson, Aleksandra D Chybowska, Camilla Drake, Poppy Adkin, Spyros I Vernardis, Arturas Grauslys and 11 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Hannah M SmithInstitute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.ORCID 0000-0002-2972-821X
Joanna E MoodieLothian Birth Cohorts, Department of Psychology, University of Edinburgh, Edinburgh, UK.ORCID 0000-0003-0404-6295
Gail DaviesLothian Birth Cohorts, Department of Psychology, University of Edinburgh, Edinburgh, UK.
Anne RichmondInstitute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.
Josephine A RobertsonInstitute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.
Aleksandra D ChybowskaInstitute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.
Camilla DrakeMRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, UK.
Poppy AdkinEliptica Limited, The London Cancer Hub, Cotswold Road, Sutton, London, UK.
Spyros I VernardisEliptica Limited, The London Cancer Hub, Cotswold Road, Sutton, London, UK.
Arturas GrauslysEliptica Limited, The London Cancer Hub, Cotswold Road, Sutton, London, UK.
Matthew E H WhiteThe Francis Crick Institute, Molecular Biology of Metabolism Laboratory, London, UK.
Sergej AndrejevEliptica Limited, The London Cancer Hub, Cotswold Road, Sutton, London, UK.
Charles BrigdenEliptica Limited, The London Cancer Hub, Cotswold Road, Sutton, London, UK.
Christoph B MessnerThe Francis Crick Institute, Molecular Biology of Metabolism Laboratory, London, UK.
Caroline HaywardMRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, UK.
Aleksej ZelezniakEliptica Limited, The London Cancer Hub, Cotswold Road, Sutton, London, UK.
Markus RalserEliptica Limited, The London Cancer Hub, Cotswold Road, Sutton, London, UK.
Ilse KrätschmerInstitute of Science and Technology Austria, Am Campus 1, 3400 Klosterneuburg, Austria.
Matthew R RobinsonInstitute of Science and Technology Austria, Am Campus 1, 3400 Klosterneuburg, Austria.
Simon R CoxLothian Birth Cohorts, Department of Psychology, University of Edinburgh, Edinburgh, UK.
Riccardo E MarioniInstitute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.

Funding

Evaluating Longitudinal Changes in the Human Structural Connectome in Relation to Cognitive AgingR01AG054628 · NIA · UNIVERSITY OF TEXAS AT AUSTIN · PI TUCKER-DROB, ELLIOT MAX · 2017 to 2021
$2.7M
NIA NIH HHS R01 AG054628Wellcome Trust
6 · The paper itself

Abstract

Untargeted mass spectrometry remains underutilised for blood-based biomarker discovery in dementia research from large cohorts, where affinity-based approaches dominate. To address this, we examined mass-spectrometry-derived proteomic correlates of cognitive function, genetic predisposition to cognitive health,

Identifiers

PMID41646675
PMCPMC12870586

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.