Evidence map›Paper›PMID 41646626›Full record

ArticleCHEST pulmonary2025

Sarcoidosis and Risk of Nephrolithiasis in US Black Women: Data from the Black Women's Health Study.

Theresa R McAllister, Praveen Govender, Jacqueline M Hicks, Shaun E L Wason, Yvette C Cozier

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in CHEST pulmonary, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Theresa R McAllisterDepartment of Epidemiology (T. R. M. and Y. C. C.), Boston University School of Public Health; the Department of Pulmonary, Allergy, Sleep, and Critical Care Medicine (P. G.), Boston University School of Medicine; The Sarcoidosis Clinic at Boston Medical Center (P. G.); the Department of Biostatistics (J. M. H.), Boston University School of Public Health; the Division of Urology (S. E. L. W.), Beth Israel Deaconess Medical Center; and the Slone Epidemiology Center at Boston University (Y. C. C.), Boston, MA.
Praveen GovenderDepartment of Epidemiology (T. R. M. and Y. C. C.), Boston University School of Public Health; the Department of Pulmonary, Allergy, Sleep, and Critical Care Medicine (P. G.), Boston University School of Medicine; The Sarcoidosis Clinic at Boston Medical Center (P. G.); the Department of Biostatistics (J. M. H.), Boston University School of Public Health; the Division of Urology (S. E. L. W.), Beth Israel Deaconess Medical Center; and the Slone Epidemiology Center at Boston University (Y. C. C.), Boston, MA.
Jacqueline M HicksDepartment of Epidemiology (T. R. M. and Y. C. C.), Boston University School of Public Health; the Department of Pulmonary, Allergy, Sleep, and Critical Care Medicine (P. G.), Boston University School of Medicine; The Sarcoidosis Clinic at Boston Medical Center (P. G.); the Department of Biostatistics (J. M. H.), Boston University School of Public Health; the Division of Urology (S. E. L. W.), Beth Israel Deaconess Medical Center; and the Slone Epidemiology Center at Boston University (Y. C. C.), Boston, MA.
Shaun E L WasonDepartment of Epidemiology (T. R. M. and Y. C. C.), Boston University School of Public Health; the Department of Pulmonary, Allergy, Sleep, and Critical Care Medicine (P. G.), Boston University School of Medicine; The Sarcoidosis Clinic at Boston Medical Center (P. G.); the Department of Biostatistics (J. M. H.), Boston University School of Public Health; the Division of Urology (S. E. L. W.), Beth Israel Deaconess Medical Center; and the Slone Epidemiology Center at Boston University (Y. C. C.), Boston, MA.
Yvette C CozierDepartment of Epidemiology (T. R. M. and Y. C. C.), Boston University School of Public Health; the Department of Pulmonary, Allergy, Sleep, and Critical Care Medicine (P. G.), Boston University School of Medicine; The Sarcoidosis Clinic at Boston Medical Center (P. G.); the Department of Biostatistics (J. M. H.), Boston University School of Public Health; the Division of Urology (S. E. L. W.), Beth Israel Deaconess Medical Center; and the Slone Epidemiology Center at Boston University (Y. C. C.), Boston, MA.

Funding

A Follow-up Study for Causes of Cancer in Black WomenU01CA164974 · NCI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI Kimberly A. Bertrand, Yvette C Cozier · 2017 to 2026
$24.0M
FOLLOW-UP STUDY FOR CAUSES OF ILLNESS IN BLACK WOMENR01CA058420 · NCI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI ROSENBERG, LYNN · 1999 to 2013
$20.7M
A Follow-up Study for Causes of Cancer in Black WomenUM1CA164974 · NCI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI ROSENBERG, LYNN · 2012 to 2017
$13.7M
Sarcoidosis in U.S. Black Women: Genetic and Non-genetic Risk FactorsK01HL088709 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI COZIER, YVETTE C · 2008 to 2012
$590k
NCI NIH HHS R01 CA058420NCI NIH HHS U01 CA164974NCI NIH HHS UM1 CA164974NHLBI NIH HHS K01 HL088709
6 · The paper itself

Abstract

backgroundSarcoidosis is a systemic inflammatory disorder linked to dysregulation of vitamin D metabolism. This state can contribute to abnormalities in calcium metabolism, theoretically increasing the risk of nephrolithiasis (kidney stones). Sarcoidosis and risk factors for nephrolithiasis (type 2 diabetes mellitus and hypertension) are common among US Black women. RESEARCH QUESTION: How does sarcoidosis affect the risk of nephrolithiasis in a cohort of US Black women? Does the association change by the number and type of cooccurring metabolic condition? STUDY DESIGN AND

methodsWe conducted a cross-sectional analysis using data from the Black Women's Health Study (BWHS), a study of 59,000 US Black women 21 to 69 years of age in 1995 (baseline). Information on sarcoidosis and covariates was obtained from baseline and biennial follow-up questionnaires through 2005. The 2005 questionnaire ascertained diagnoses of nephrolithiasis. We estimated ORs and 95% CIs using logistic regression adjusting for covariates, including calcium and vitamin D supplementation, alcohol consumption, and metabolic conditions (obesity, type 2 diabetes mellitus, hypertension, and hyperlipidemia). We repeated analyses within strata of number of metabolic conditions.

resultsThe analytical sample consisted of 43,718 women who completed the 2005 BWHS questionnaire. Between 1995 (baseline) and 2005, a total of 832 women reported sarcoidosis. As of 2005, of the women reporting sarcoidosis, 3.9% reported a history of nephrolithiasis, compared with 1.9% of the nonsarcoidosis participants. Among women with sarcoidosis, compared with those without, the odds of nephrolithiasis were 1.80 (95% CI, 1.25-2.59). The association according to number of metabolic conditions (none, 1-2, and 3-4) was additionally increased for women with 3 to 4 cooccurring conditions: 1.96 (95% CI, 1.09-3.52).

interpretationOur results indicate that US Black women with sarcoidosis have an increased risk of nephrolithiasis. The findings highlight the importance of monitoring for signs of vitamin D and calcium dysregulation in the management of sarcoidosis, especially among those with cooccurring metabolic conditions.

Indexed as

African AmericanBlackkidney stonesnephrolithiasissarcoidosiswomen

Identifiers

PMID41646626
PMCPMC12872044

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.