Evidence map›Paper›PMID 41646596›Full record

ArticleCureus2026

Unveiling the Uncommon: A Rare IgE-Mediated Presentation of Multiple Drug Hypersensitivity Syndrome.

Ana Vitória Soares, Diogo Mota, Daniela Brandão Abreu, Eunice Dias-Castro, Leonor Carneiro-Leão

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ana Vitória SoaresAllergy and Clinical Immunology Department, Centro Hospitalar Universitário São João, Porto, PRT.
Diogo MotaAllergy and Clinical Immunology Department, Centro Hospitalar Universitário São João, Porto, PRT.
Daniela Brandão AbreuAllergy and Clinical Immunology Department, Centro Hospitalar Universitário São João, Porto, PRT.
Eunice Dias-CastroAllergy and Clinical Immunology Department, Centro Hospitalar Universitário São João, Porto, PRT.
Leonor Carneiro-LeãoAllergy and Clinical Immunology Department, Centro Hospitalar Universitário São João, Porto, PRT.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Multiple drug hypersensitivity syndrome (MDHS) is characterized by hypersensitivity reactions to two or more unrelated drugs. Although it is commonly associated with delayed reactions, we report a rare case of immediate IgE-mediated MDHS in a 30-year-old female who reacted to levofloxacin and ibuprofen. Both reactions were confirmed through drug challenges, while acetylsalicylic acid was tolerated, excluding COX-1 cross-reactivity. This case highlights the importance of recognizing IgE-mediated MDHS and performing thorough allergy diagnostic workups to ensure accurate management and patient safety.

Indexed as

ige-mediatedmrgprx2 receptormultiple drug hypersensitivity syndromensaids hypersensitivityquinolones

Identifiers

PMID41646596
PMCPMC12872274

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.