ReviewCureus2026
Early Postoperative Endothelial Cell Density Predicts Graft Survival After Keratoplasty: A Systematic Review and Meta-Analysis.
Review in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Long-term graft clarity after corneal transplantation depends on sustained endothelial survival, yet the prognostic role of early postoperative endothelial metrics has not been clearly synthesized. We therefore reviewed longitudinal clinical evidence and quantitatively summarized the relationship between early postoperative endothelial status and later endothelial failure-related graft failure across common keratoplasty techniques. Overall, lower endothelial reserve measured in the early postoperative period consistently aligned with higher subsequent failure risk, with suggestive signals that risk may rise steeply below certain low-density ranges, while a minority of grafts can remain clear despite very low counts. Limited data also indicate that some endothelial morphological features may add prognostic value beyond cell density. These findings support using early postoperative endothelial assessment as part of practical risk stratification and follow-up planning, alongside measures aimed at preserving endothelial reserve to help extend graft longevity.
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Registered trials
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