Evidence map›Paper›PMID 41646544›Full record

ArticleAdvanced functional materials2026

Engineering Drug-Eluting Ocular Bioadhesive "OcuTAPE" via Tannic Acid-Mediated Nanoparticle Bridging.

Yuting Zheng, Monu Monu, Steven Vo, Suneel Gupta, Lal Krishan Kumar, Prince Kumar, Nariman Nassiri, Pawan Kumar Singh, Nasim Annabi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced functional materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yuting ZhengDepartment of Chemical and Biomolecular Engineering, University of California, Los Angeles, Los Angeles, California 90095, USA.
Monu MonuDepartment of Ophthalmology, Mason Eye Institute, University of Missouri School of Medicine, Columbia, MO 65201, USA.
Steven VoDepartment of Chemical and Biomolecular Engineering, University of California, Los Angeles, Los Angeles, California 90095, USA.
Suneel GuptaHarry S. Truman Memorial Veterans' Hospital, Columbia, MO 65201, USA.
Lal Krishan KumarDepartment of Ophthalmology, Mason Eye Institute, University of Missouri School of Medicine, Columbia, MO 65201, USA.
Prince KumarDepartment of Ophthalmology, Mason Eye Institute, University of Missouri School of Medicine, Columbia, MO 65201, USA.
Nariman NassiriGlaucoma Division, Department of Ophthalmology, UCLA Doheny Eye Institute, Pasadena, CA 91105, USA.
Pawan Kumar SinghDepartment of Ophthalmology, Mason Eye Institute, University of Missouri School of Medicine, Columbia, MO 65201, USA.
Nasim AnnabiDepartment of Chemical and Biomolecular Engineering, University of California, Los Angeles, Los Angeles, California 90095, USA.

Funding

Engineering a naturally derived and highly adhesive surgical sealantR01EB023052 · NIBIB · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ANNABI, NASIM, KHADEMHOSSEINI, ALI · 2017 to 2022
$2.4M
Role of Zika virus (ZIKV) infection in glaucoma pathobiologyR01EY032495 · NEI · UNIVERSITY OF MISSOURI-COLUMBIA · PI SINGH, PAWAN KUMAR · 2021 to 2025
$2.0M
NEI NIH HHS R01 EY032495NIBIB NIH HHS R01 EB023052
6 · The paper itself

Abstract

Dynamic integration of nanoparticles (NPs) into hydrogels remains a key challenge in engineering drug-eluting bioadhesives. A generalizable strategy leveraging the multifunctional binding capacity of tannic acid (TA) to bridge drug-loaded NPs and hydrogel via hydrogen bonding is presented. Acting as both a bioadhesive moiety and dynamic crosslinker, TA enables synthesis-free NP incorporation and facilitates versatile nanocomposite designs for sustained, localized drug delivery. To demonstrate clinical relevance, a ready-to-use ocular patch named 'OcuTAPE' is developed to address the unmet need for bioadhesives that seal injuries and provide sustained drug release. Current ocular adhesives suffer from poor retention, mechanical mismatch, uncontrolled drug release, and limited usability. OcuTAPE achieves high toughness (≈4000 kJ m

Indexed as

anti-inflammatory therapybioadhesive hydrogelocular patchsustained drug releasetannic acid-bridged nanocomposite

Identifiers

PMID41646544
PMCPMC12872175

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.