ArticleFrontiers in oncology2026
Malignant nodular fasciitis, a rare manifestation of a benign disease: case report.
Article in Frontiers in oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
Nodular fasciitis is a common benign tumor resulting from reactive proliferation of fibroblasts and myofibroblasts. It most often presents as a firm and solitary lump in the subcutaneous fat layer or fascia adjacent to muscles in the extremities. Because of its rapid growth and high cellularity, it may mimic soft-tissue sarcoma, but it is self-limiting, often resolving with fibrosis. The evolution of benign nodular fasciitis to malignant nodular fasciitis is distinctly uncommon, and only a handful of cases have been reported in the medical literature. Herein we describe the case of a woman with a 21-year history of multifocal nodular fasciitis superimposed on malignant nodular fasciitis. Her course has been characterized by rapid tumor growth and widespread dissemination. Over the course of 2l years she underwent multiple surgical procedures. Ultimately, molecular studies demonstrated a fusion of protein phosphatase 6 regulatory subunit 3 (
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