ArticleResearch square2026
Cancer histone H2A.Z missense mutations disrupt function through distinct local and allosteric effects.
Article in Research square, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
H2A.Z is a conserved variant of histone H2A that functions in a wide range of processes including transcriptional, chromatin organization, and genome stability, but whose exact role in the cell remains incompletely understood. A growing body of literature highlights the utility of cancer histone missense mutations in revealing fundamental aspects of histone structure and function not captured by previous efforts including comprehensive alanine scans. Motivated by this work, we systematically examined the impact of cancer missense mutations affecting H2A.Z using
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.